Current adjuvant treatment guidelines for oropharyngeal squamous cell carcinoma treated with primary surgery are based on studies that predate the human papillomavirus (HPV) era. HPV-associated oropharynx carcinoma (HPV-OPC) has a much more favorable prognosis compared to HPV-unassociated cancer and is increasingly considered to be a distinct disease entity due to its unique etiology, presentat...

The interaction of a frontal system with the extreme orography of the Andes mountain range is examined for a case of intense precipitation in central Chile during June 2002. The heavy rainfall was associated with a synoptic scale rainband that moved slowly over central Chile during a 48 hour period. Numerical simulations with the WRF mesoscale model show that both the intensification of precipi...

This paper describes a slope scaling heuristic for solving the multicomodity capacitated fixed-charge network design problem. The heuristic integrates a Lagrangean perturbation scheme and intensification/diversification mechanisms based on a long-term memory. Although the impact of the Lagrangean perturbation mechanism on the performance of the method is minor, the intensification/diversificati...

FAO promotes Sustainable Production Intensification (SPI), which consists of a technology menu for optimizing crop production per unit area, taking into consideration the range of sustainability aspects including potential and/or real social, political, economic and environmental impacts. The author suggests that Genetically Modified Organism (GMO) cropping is not only well aligned to SPI but a...

A paper read to a Conference of Physicians of the South-East Metropolitan Region at the Brook Hospital, March I7, I962. strate the value of this in a case of pulmonary valvular stenosis. (ii) Intensification of the fluoroscopic image with television monitoring. This assists in screening and the placement of catheters and avoids the necessity for dark adaptation and darkening of the screening ro...

This paper presents results of investigations on the application of CuO-water nanofluids for intensification of convective heat transfer. Performance of nanofluids with 2.2 and 4.0 vol.% CuO NPs (nanoparticles) content were examined with regard to heat transfer coefficient and pressure losses in case of turbulent flow in a tube. Negligible impact of examined nanofluid on heat transfer improveme...

A substantial proportion of patients with type 2 diabetes mellitus do not reach glycemic targets, despite treatment with oral anti-diabetic drugs and basal insulin therapy. Several options exist for treatment intensification beyond basal insulin, and the treatment paradigm is complex. In this review, the options for treatment intensification will be explored, focusing on drug classes that act v...