Abstract This paper, written in honor of Professor Ed Zigler, focuses on some the themes developmental disabilities research that were so central to his work. It has now been nearly 80 years since Leo Kanner first identified prototypic form – early infantile autism what is spectrum disorder. In this article we summarize development concept and important accumulation knowledge over time led us r...

Neurodevelopmental disorders such as attention deficit hyperactivity disorder and autism represent a significant economic burden, which justify vigorous research to uncover its genetics and developmental clinics for a diagnostic workup. The urgency of addressing attention deficit hyperactivity disorder comorbidities is seen in the chilling fact that attention deficit hyperactivity disorder (ADH...

OBJECTIVE Many patients with late-diagnosed phenylketonuria (PKU) suffer from severe behavior problems. This study compares the effects of buspirone and risperidone on reducing behavior disorders in these patients. MATERIALS & METHODS In this crossover clinical trial study, patients with severe behavior disorders after medical examination were randomly divided into two groups of two 8-week cr...

background motor skills disorder in children with motor dys-function is a common disorder in childhood. the aim of this study was to investigate the prevalence and severity of musculoskeletal disorders in children with developmental coordination disorder in comparison with healthy children. material and methods using developmental disorder coordina-tion questionnaire (dcdq'07), 59 male children...

It has been reported that the clinical presentation of forced normalization can vary from paranoid hallucinatory states to anxiety and conversion phenomena, and that it may occur in both generalised and focal epilepsies. On the basis of the evaluation of a video recording, we found that forced normalization was concomitant with catatonic psychosis in a patient with epilepsy, intellectual disabi...

Baraitser-Winter cerebrofrontofacial syndrome (BWCFF) (BRWS; MIM #243310, 614583) is a rare developmental disorder affecting multiple organ systems. It is characterised by intellectual disability (mild to severe) and distinctive facial appearance (metopic ridging/trigonocephaly, bilateral ptosis, hypertelorism). The additional presence of cortical malformations (pachygyria/lissencephaly) and oc...

A 44-year-old woman presented with childhood-onset refractory complex partial seizures. Medical history revealed neonatal macrosomia and hypotonia, early-onset overgrowth in infancy, macrocephaly and mild intellectual disability. Examination revealed macrodolichocephaly with prominent forehead and facial dysmorphisms, scoliosis, large hands and arachnodactyly (Figure 1). Neuroimaging showed mac...