Histoplasma capsulatum var. capsulatum is a dimorphic fungus that causes histoplasmosis, a human systemic mycosis with worldwide distribution. In the present work, we demonstrate that H. capsulatum yeasts are able to induce cytokine secretion by the human lung epithelial cell line A549 in integrin- and Src-family kinase (SFK)-dependent manners. This conclusion is supported by small interfering ...

Chemoattractants differ in their capacity to stimulate neutrophils to adhere to and to migrate through matrices containing fibrin. Formyl methionyl leucyl phenylalanine (fMLP) stimulates neutrophils to adhere closely to, but not to migrate into, fibrin gels. Leukotriene B4 (LTB4) stimulates neutrophils to adhere loosely to and to migrate through fibrin gels. We report that a 5 b 1 integrins reg...

Leucocyte function-associated antigen 1 (LFA-1; also known as CDlldCD18) belongs to the family of integrins which is one of the most important families of cell adhesion molecules and includes receptors that bind to the extracellular matrix as well as receptors involved in cell-cell interactions. Recent findings have demonstrated that integrins are both adhesion receptors and signalling molecule...

1. Abstract 2. Introduction 3. Discussion 3.1. β2 integrin engagement induces activation of tyrosine kinases 3.1.1 Activation of src family tyrosine kinases 3.1.2. Activation of Syk 3.1.3. Activation of tyrosine kinases of the FAK family 3.2. Proteins that are tyrosine phosphorylated upon β2 integrin engagement in leukocytes 3.2.1. The docking protein Cbl 3.2.2. The guanine nucleotide exchange ...

Leukocytes (neutrophils, monocytes) in the active circulation exhibit multiple phenotypic indicators for a low level of cellular activity, like lack pseudopods and minimal amounts activated, cell-adhesive integrins on their surfaces. In contrast, before these cells enter bone marrow or when they recross endothelium into extravascular tissues peripheral organs are fully activated. We review here...

Cells over-expressing integrins or CCR6 were incubated on a DNA microarray, pre-hybridized with a 10,000 member PNA-encoded peptide library allowing novel cell specific ligands for integrins and CCR6 to be identified.

After neoplastic cells leave the primary tumor and circulate, they may extravasate from the vasculature and colonize tissues to form metastases. β1 integrins play diverse roles in tumorigenesis and tumor progression, including extravasation. In blood cells, activation of β1 integrins can be regulated by "inside-out" signals leading to extravasation from the circulation into tissues. However, a ...