Adrenal insufficiency is a potential complication of therapy with an inhaled corticosteroid (ICS). Although prior studies found the highest risk of adrenal insufficiency with fluticasone, a more potent ICS, these results might be explained by a channelling bias and concomitant exposure to oral corticosteroids. We re-examined the relationship between the use of ICSs and adrenal insufficiency by ...

objective we describe three patients with very severe spinal muscular atrophy (sma) presented with reduced fetal movement in utero, profound hypotonia, severe weakness and respiratory insufficiency at birth. in all infants, electrodiagnostic studies were compatible with a neurogenic pattern. in genetic studies, all cases had homozygous deletions of exons 7 and 8 of survival motor neuron (smn) a...

The combination of Müllerian agenesis with inguinal ovaries accompanied by primary ovarian insufficiency is extremely rare. A 21-year-old Korean woman was referred to our center with primary amenorrhea. The patient was diagnosed with Müllerian agenesis with inguinal ovaries. Her hormonal profile showed hypergonadotrophic hypogonadism suggesting primary ovarian insufficiency. We performed laparo...

Allgrove (Triple A) syndrome is a rare autosomal recessive disorder characterized by cardinal features of adrenal insufficiency due to adrenocorticotropic hormone (ACTH) resistance, achalasia, and alacrimia. It is frequently associated with neurological manifestations like polyneuropathy. Since its first description by Allgrove in 1978, approximately 100 cases have been reported in the literatu...

Insufficiency fracture is of the stress fractures and is caused by repetitive stress on fragile bone. Insufficiency fractures of pubic rami are rare occurrences in association with total hip arthroplasty (THA). Postoperative stress fractures occur due to increase of patients activity following years of disability. The physician should consider the possibility of a pelvic insufficiency fracture ...

Most cardiodynamic indices including positive and negative left ventricular (LV) dp/dt, and the ratio of either to left ventricular end diastolic presmre (LVEDP) as well as to each other, deviate in nearly identical fashion with both myocardial impairment and preejection ventricular unloading of the type seen in mitral insufficiency. Because peak contractile element velocity is an early preejec...

The study of placental lactogen by immunohistochemistry in histological sections the placenta during physiological pregnancy and on background iron deficiency anemia aspect chronic insufficiency. It is established that gestation against decreases production syncytiotrophoblast chorionic villi correlates with state blood pregnant woman. optical density immunohistochemical staining for free troph...

Background/ObjectiveInfiltrative fungal infections are an unusual cause of primary adrenal insufficiency (AI). Our objective is to present long term follow-up a patient with AI due crytpococcal adrenalitis.Case ReportA 47 year old woman presented in January 2004 50 lb. weight loss, nausea, emesis, and headache diplopia. During the 6 months prior her presentation had multiple admissions for eval...