The function of inspiratory muscles is crucial for effective cough as well as expiratory muscles in patients with Duchenne muscular dystrophy (DMD). However, there is no report on the correlation between cough and inspiratory muscle strength. To investigate the relationships of voluntary cough capacity, assisted cough techniques, and inspiratory muscle strength as well as expiratory muscle stre...

The measurement of the mechanical work of breathing (WOB) has been used in clinical research for over four decades and has provided valuable insights into the pathophysiological derangements that exist in patients with chronic obstructive pulmonary disease (COPD). These WOB calculations are based on the principle that work is performed when pressure changes the volume of the respiratory system....

➥ normal inspiration and expiration. In adults it is about 700 ml (10 ml/kg). Expiratory reserve volume (ERV) is the gas volume additionally exhaled during forced expiration and inspiratory reserve volume (IRV) is that after a forced inspiration. The sum of VT and IRV is the inspiratory capacity (IC). Even after a maximum expiratory effort, some air is left in the lung; no lung region normally ...

introduction:the assessment of intravascular volume in severely traumatized patients or patients admitted in icu is very essential. at present the accurate method for estimating the intravascular volume requirement is by measuring the cvp which is an invasive method. the measurement of ivc diameter by ultrasound has been suggested as an easily available and simple method for measuring the intra...

Hypothermia was shown to attenuate ventilator-induced lung injury due to large tidal volumes. It is unclear if the protective effect of hypothermia is maintained under less injurious mechanical ventilation in animals without previous lung injury. Tracheostomized rats were randomly allocated to non-ventilated group (group C) or ventilated groups of normothermia (group N) and mild hypothermia (gr...

The purpose of this study, in patients with chronic obstructive pulmonary disease (COPD), was to examine the relationship of dyspnoea, rated on a visual analogue scale (VAS), to 1) tidal ventilatory variables measured on exercise and 2) pre-exercise lung function. Twenty one patients (forced expiratory volume in one second (FEV1) mean (SD) 1.19 (0.32) l) were studied. During a preliminary test,...

INTRODUCTION The effect of leaks on volume-targeted pressure support noninvasive ventilation mode has only been tested with continuous simulated leaks. The objective of the study was to assess the influence of random leaks occurring either during inspiration or expiration. METHODS Analysis of the volume-targeted pressure support mode in 6 commercial ventilators with single-limb circuits and i...

We determined the role of expiratory flow limitation (EFL) on the ventilatory response to heavy exercise in six trained male cyclists [maximal O2 uptake = 65 +/- 8 (range 55-74) ml. kg-1. min-1] with normal lung function. Each subject completed four progressive cycle ergometer tests to exhaustion in random order: two trials while breathing N2O2 (26% O2-balance N2), one with and one without adde...

The main supportive therapy in acute respiratory distress syndrome patients is mechanical ventilation. As with any therapy, mechanical ventilation has side-effects, and may induce lung injury (ventilator-induced lung injury (VILI)/ventilator-associated lung injury). The mechanical factors responsible for VILI are thought to be related to tidal recruitment/derecruitment of previously collapsed a...