Repurposing of existing cancer drugs to overcome their physical limitations, such as insolubility, represents an attractive strategy to achieve enhanced therapeutic efficacy and broaden the range of clinical applications. Such an approach also promises to offer substantial cost savings in drug development efforts. Here we repurposed FDA-approved topical agent bexarotene (Targretin), currently i...

Assembly of herpes simplex viruses (HSV) is a poorly understood process involving multiple redundant interactions between large number of tegument and envelope proteins. We have previously shown (G. E. Lee, G. A. Church, and D. W. Wilson, J. Virol. 77:2038-2045, 2003) that the virion host shutoff (Vhs) tegument protein is largely insoluble in HSV-infected cells and is also stably associated wit...

Apolipoprotein B, the major protein component of very-low-density (VLDL) and low-density (LDL) lipoproteins in serum, is being widely measured in serum, to help assess risk of cardiovascular disease. Standardization has proven difficult because of the physical and immunochemical heterogeneity of LDL and VLDL, the masking of antigenic determinants of LDL and VLDL, the insolubility of apolipoprot...

Accurate analysis of the main chemical components oil-bearing sludge is an important prerequisite for effective soil remediation and resource reuse. However, precise extract difficult to achieve because mutual interference saturates, aromatics, resins, collectively called SAR, asphaltene that are introduced during chloroform extraction. In this study, SAR was efficiently extracted using n-hepta...

Lithium-ion battery (LIB) recycling has received continued interest in recent years due to its benefits, which include reducing the environmental impact of spent LIBs and providing a secondary source valuable metals, such as Li, Co, Ni. This paper characterized Li separation with D2EHPA from citrate media function pH identified optimal overall at 5.5. The was optimized 5.5, it concluded that 23...

The present study aimed to characterize melanin pigment extracted from Gluconobacter oxydans FBFS 97. After 14 days of culture at 28 °C in GY (glucose and yeast extract) liquid-state medium, G. FBFS97 produce the maximum melanin, up about 12–15 mg/L. physicochemical characteristics showed an ability dissolve 1 mol/L NaOH or KOH, insolubility water most organic solvents, such as chloroform petro...

Abstract. Thanks to its insolubility, mineral dust is considered a stable proxy in polar ice cores. With this study we show that the Talos Dome core (TALDICE, Ross Sea sector of East Antarctica) displays evident and progressive signs post-depositional processes affecting record below 1000 m deep. We apply suite established cutting-edge techniques investigate properties TALDICE, ranging from con...

Phthalocyanines (Pcs) are 18-electron π-conjugated macrocyclic ring systems with proven activities in diverse fields, including pharmaceuticals and catalysis. These demonstrated often alluded to as their fascinating photophysical photochemical dispositions, which usually dependent on molecular structures. However, many of these molecules suffer from aggregation due π–π stacking have limited ins...

The ability of low boiling point liquid perfluorocarbons (PFCs) to undergo a phase change from a liquid to a gas upon ultrasound irradiation makes PFC-based emulsions promising vehicles for triggered delivery of payloads. However, loading hydrophilic agents into PFC-based emulsions is difficult due to their insolubility in PFC. Here, we address this challenge by taking advantage of microfluidic...

In using a monoclonal antibody against a major cytoplasmic protein of 46,000 mol wt, we have characterized an intermediate-sized (10 nm) filamentous cytoskeleton in Drosophila melanogaster tissue culture cells. Indirect immunofluorescence, immunoelectron microscopy, and protein blotting show that this cytoskeleton exhibits features typical of the vertebrate vimentin cytoskeleton, including the ...