Epinephrine and calcium possess both cardiac inotropic and vasopressor activity. In addition, epinephrine's cardiovascular effects are mediated via increases in intracellular calcium. As a result, many clinicians administer the two agents together in an attempt to augment their effects. Although this approach seems rational, it has never been proven effective. We evaluated the cardiovascular an...

BACKGROUND Left ventricular dysfunction is common after coronary artery bypass graft and valve replacement surgeries and is often treated with inotropic drugs to maintain adequate hemodynamic status. In this study, we aimed to identify the demographic, clinical, laboratory, echocardiographic and hemodynamic factors that are associated with use of inotropic drugs in patients undergoing concomita...

Faucher FA, Gannier FE, Lignon JM, Cosnay P, Malécot CO. Roles of PKA, PI3K, and cPLA2 in the NO-mediated negative inotropic effect of 2-adrenoceptor agonists in guinea pig right papillary muscles. Am J Physiol Cell Physiol 294: C106–C117, 2008. First published October 17, 2007; doi:10.1152/ajpcell.00231.2007.— Although 2-adrenoceptors represent 15–25% of -adrenoceptors in the guinea pig heart,...

Pharmacological examinations of isolated auricles from Sepia officinalis were carried out to analyze the putative role of the monoaminergic transmitter/receptor system in the control of auricle function. In conjunction with histofluorescence studies and HPLC analyses, evidence of a double excitatory serotonergic and noradrenergic innervation of the auricles was obtained. Serotonin-induced posit...

BACKGROUND Adenosine attenuates beta-adrenoceptor-mediated inotropic responses through GTP-binding protein in vitro. The goal of the present study was to test the hypothesis that endogenous adenosine released from the ischemic myocardium blunts the inotropic response to beta-adrenergic stimulation. METHODS AND RESULTS In 45 open-chest dogs, the left anterior descending coronary artery was per...

The administration of single large doses of angiotensin II has been shown to elicit positive chronotropic and inotropic effects in isolated heart preparations."' Continuous infusions of this hormone in normotensive animals, however, in amounts sufficient to produce marked vasoconstrictor responses, elicit only infrequent and transient increases of contractility.! Occasionally, negative inotropi...

Michael J. Antonaccio and Benedict R. Lucchesi Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48104 (Received 22 May 1970 ; in final form 3 August 1970) Glucagon has been shown to be both a positive inotropic and chronotropic agent in many species including man (1-5). However, the positive inotropic effect of glucagon on dog papillary muscles can be r...

During the winter months, high doses of acetylcholine produced positive inotropic action without any chronotropic action on the perfused atropinised frog heart, in 5 out of 24 preparations. In the remaining preparations acetylcholine failed to produce any action and positive inotropic effect of acetylcholine on these preparations was noticed if they were perfused with the medium containing exce...

The aim of this study was to examine racial differences in long-term mortality after coronary artery bypass grafting (CABG), stratified by preoperative use of inotropic agents. Black and white patients who required preoperative inotropic support prior to undergoing CABG procedures between 1992 and 2011 were compared. Mortality probabilities were computed using the Kaplan-Meier product-limit met...

We report a case of a 45-year-old female undergoing an emergency ventriculoperitoneal shunt surgery. The patient had brain metastatic lesions of breast carcinoma with associated hydrocephalus. She had received Adriamycin as a part of chemotherapy regimen for breast cancer. Her preoperative cardiovascular status was normal. Under general anesthesia, the patient had a sudden cardiovascular collap...