Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, the current drug combination therapy refers to administering individual drugs together, which is far from a perfect regimen for cancer patients. The aim of this work was to demonstrate that syner...

Sale of medicines is not rigorously controlled in Pakistan. Therefore, medical students start prescribing drugs and advising diagnostic tests before they graduate. This cross-sectional study investigated the frequency of independent medical prescription by 180 stratified, randomly selected final year medical students from 3 public medical colleges in Punjab, Pakistan. Data were obtained by self...

Gestational diabetes mellitus (GDM) is a serious and frequent concern in pregnancy. Worldwide, the prevalence of GDM ranges from 8 to 20%. In 5% cases, this pathology accompanied by complications such as diabetic fetopathy, preeclampsia, neonatal hypoglycemia, hyperbilirubinemia. Modern national foreign guidelines for detecting hyperglycemia during pregnancy diagnosing recommend lifestyle chang...

It has been established that some nonsteroidal anti-inflammatory drugs (NSAIDs) when administered through injectable preparations have a local irritating effect, even though the are considered high-quality. seems this irritant action is not related to any specific pharmacological but with physicochemical properties of preparation grossly violate homeostasis tissues. complications at injection s...

UNLABELLED Clinicians have had concerns about particulate matter contamination of injectable drug products since the development of the earliest intravenous therapeutics. All parenteral products contain particulate matter, and particulate matter contamination still has the potential to cause harm to patients. With tens of millions of doses of injectable drug products administered in the United ...

Prohibition of illegal drugs is a failed social policy and new models of regulation of these substances are needed. This paper explores a proposal for a post-prohibition, public health based model for the regulation of the most problematic drugs, the smokable and injectable stimulants. The literature on stimulant maintenance is explored. Seven foundational principles are suggested that could su...

BACKGROUND KYBELLA, ATX-101, is an injectable form of sodium deoxycholic acid. It is currently the only Food and Drug Administration-approved injectable drug for the reduction of submental fat. OBJECTIVES A literature review and discussion of the treatment of submental fat. RESULTS KYBELLA is a well-tolerated alternative for the treatment of submental fat. CONCLUSIONS KYBELLA is a safe an...

BACKGROUND Oral contraceptives are known to influence the risk of cancers of the female reproductive system. Evidence regarding the relationship between injectable contraceptives and these cancers is limited, especially in black South Africans, among whom injectable contraceptives are used more commonly than oral contraceptives. METHODS AND FINDINGS We analysed data from a South African hospi...

OBJECTIVE To compare associations between vaccine types and other injectable drugs with development of injection-site sarcomas in cats. DESIGN Case-control study. ANIMALS 181 cats with soft tissue sarcomas (cases), 96 cats with tumors at non-vaccine regions (control group I), and 159 cats with basal cell tumors (control group II). PROCEDURES Subjects were prospectively obtained from a lar...