After an initial stimulation of human monocyte-derived macrophages with bacterial lipopolysaccharide (LPS), which produces substantial release of tumor necrosis factor-alpha (TNF-alpha), a subsequent exposure to LPS results in about an order-of-magnitude reduction in the levels of TNF-alpha released. We have shown that macrophages which have been stimulated with LPS and then maintained in cultu...

background loss of motion is a well-known complication after elbow trauma and in severe cases, arthrolysis of elbow is the procedure of choice. the posterior approach might have some advantages especially in post-traumatic patients who have undergone the same surgical approach in the past. objectives the aim of this study was to evaluate the short-term outcomes of elbow arthrolysis through post...

background: many attempts have been performed and continued for improvement of dental amalgam properties during last decades. the aim of present research was fabrication and characterization of amalgam/titania nano composite and evaluation of its corrosion behavior. materials and methods: in this experimental research, nano particles of titania were added to initial amalgam alloy powder and the...

preparation of chitosan (cs) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low cs molecular weight (mw) was investigated in this study. diphtheria toxoid (dt) was used as a model antigen. the emulsion-solidification method was adopted for microencapsulation of dt.  in the first step, following the purification of semi-crude dt by the ion-exchan...

objective(s):  the aim of this study was to prepare a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin a.  material and methods:   formulations were designed based on full factorial design. a high pressure homogenization technique was used to produce nanosuspensions. fifteen formulations were prepared by the use of different combinations of surfa...

The aim of this study was to develop methods for the design of hydroxypropyl methylcellulose (HPMC) tablets with specified drug profiles. This was achieved by the use of a mathematical model developed to predict the release kinetics of water-soluble drugs from HPMC matrices. The required model parameters were determined experimentally for propranolol HCl and chlorpheniramine maleate in 0. 1 N H...

The aim of this study was to develop novel biomedicated nanofiber electrospun mats for controlled drug release, especially drug release directly to an injury site to accelerate wound healing. Nanofibers of poly(vinyl alcohol) (PVA), poly(vinyl acetate) (PVAc), and a 50:50 composite blend, loaded with ciprofloxacin HCl (CipHCl), were successfully prepared by an electrospinning technique for the ...

Novel bioresorbable fiber/microsphere composite structures loaded with proteins were developed and studied. These unique polymeric structures are designed to combine good mechanical properties with a desired controlled protein-release profile, in order to serve as scaffolds for tissue regeneration applications. The composite fiber structures were formed by "coating" poly(L-lactic acid) fibers w...

BACKGROUND Calcium phosphate (CaP) based nanoparticles are considered to be ideal drug carriers for delivery of anticancer drugs because of their excellent biocompatibility and pH responsiveness. However, CaP nanoparticles have the problems of limited drug load capacity, initial burst release, and short-term release. Thus, we prepared the CaP nanocomposites containing anticancer drug such as ca...