BACKGROUND Technosphere(®) insulin (TI), an inhaled human insulin with a fast onset of action, provides a novel option for the control of prandial glucose. We used the University of Virginia (UVA)/Padova simulator to explore in-silico the potential benefit of different dosing regimens on postprandial glucose (PPG) control to support the design of further clinical trials. Tested dosing regimens ...

OBJECTIVE To compare the efficacy and safety profile of adding inhaled human insulin (INH) (Exubera) or glibenclamide to metformin monotherapy in patients with poorly controlled type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted an open-label, parallel, 24-week multicenter trial. Patients uncontrolled on metformin were randomized to adjunctive INH (n = 243) or glibenclamide (n = 233). ...

Type 2 diabetes is a chronic, debilitating disease characterized by insulin resistance, impaired insulin secretion, and hyperglycaemia, and afflicting at least 171 million people worldwide (31.7 million in India). This chronic disease is not benign and patients with diabetes suffer from numerous microvascular and macrovascular complications which cause a lot of morbidity and mortality. Results ...

Insulin is usually administered to diabetic patients through subcutaneous injection. However, the various problems are encountered with subcutaneous insulin injection. Insulin cannot be administered via the oral route due to rapid enzymatic degradation in the stomach, inactivation and digestion by proteolytic enzymes, and poor permeability across intestinal epithelium .Hence various alternative...

patients and methods medical records of patients were analyzed retrospectively. results of the six patients, 83.3% (n = 5) were male and 16.7% (n = 1) were female, with a mean age of 2.1 ± 0.49 years. the most common clinical signs were dyspnea (83.3%), fever (66.6%), and vomiting (66.6%). owing to supportive treatments and the combined steroid treatment, respiratory distress diminished and the...