Ankylosing spondylitis is a chronic inflammatory disease characterized by inflammatory lower back pain and morning stiffness and accompanied by spine and sacroiliac joint involvement. Klinefelter's syndrome is a genetic condition that only affects males. Affected males have an extra X chromosome. This paper reports a 30-years-old male on followup with the diagnosis of Klinefelters syndrome. The...

Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), is associated with the persistence of pre-existing or emergence new neurological and psychiatric manifestations as a part multi-system affection known collectively “post-COVID syndrome.” Cognitive decline most prominent feature among these manifestations. The underlying neurobiologica...

Introduction CAPS is a rare autoinflammatory syndrome caused by autosomal dominant mutations in the NLRP3/CIAS 1 gene on chromosome 1q44 encoding for the cryopyrin protein, an important component of the inflammasome, leading to excessive production of interleukin-1beta (IL-1ß). CAPS encompasses three different entities of variable clinical severity: familial cold auto-inflammatory syndrome (FCA...

The novel coronavirus infection, COVID-19, is a highly contagious viral disease associated with acute, severe respiratory syndrome, which based on the development of pronounced thrombo-inflammatory syndrome. As number patients COVID-19 increased, heart damage has been reported, especially in and critical COVID-19. This review describes role angiotensin-converting enzyme 2 receptor regulation en...

The article provides an overview of key studies on vagus nerve stimulation. stimulation method affects the fibers internal and external plexuses, enhancing parasympathetic effect. positive therapeutic effect has been achieved in various experimental clinical treatment neurological cardiac diseases, metabolic syndrome, obesity. It shown that reduces epileptic seizures frequency, arrhythmias, is ...

Introduction Although all patients with chronic inflammatory conditions are at risk for developing type AA amyloidosis, the incidence varies widely between the different Autoinflammatory syndromes. The reported incidence is about 35% of patients with CAPS (cryopyrin-associated periodic syndrome) which comprises familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome and CINCA (chr...

Recently, the association of Th-17 cells or IL-17 with ocular inflammatory diseases such as uveitis, scleritis and dry eye syndrome was discovered. We assessed whether interleukin (IL)-17 was present in the tears of various ocular surface inflammatory diseases and the tear IL-17 concentrations were clinically correlated with various ocular surface inflammatory diseases. We measured concentratio...

In autoimmune conditions affecting the central and peripheral CNS as well as in multiple sclerosis (MS), the inflammatory syndrome is present with the onset of this disease. The present paper aimed to highlight the inflammatory syndrome based on the leukergia test, the total blood viscosity test, blood filterability test as well as on other tests. The early instituting of the therapeutic plasma...

Low-level transcutaneous electrical stimulation of the auricular branch vagus nerve at tragus (LLTS) is anti-arrhythmic and anti-inflammatory in animals humans. Preliminary animal studies show that LLTS beneficial models postural tachycardia syndrome (POTS).