Abstract Background Patients with intra-articular fractures tend to develop post-traumatic osteoarthritis (PTOA). The initial inflammatory response elevation of cytokines following joint trauma might be responsible for triggering cartilage catabolism and degradation. We aimed identify quantify cytokine levels in fractured healthy knee joints the correlation these clinical outcomes. Methods In t...

THE AIM OF THE STUDY The aim of the study was to investigate the serum pro-inflammatory cytokine profile in patients with diagnosed endometriosis. MATERIAL AND METHODS The study included 160 women, who were divided in two study groups (Group I - endometriosis; Group 2 - healthy). We evaluated the serum levels of interleukin (IL)-1β, IL-5, IL-6, IL-7, and IL-12, and of tumour necrosis factor α...

Cytokines are key factors in the cross talk between the immune system and other systems including hepatic, nervous, cardiac and cutaneous systems, leading to an adaptive and integrated response of the organism to stress. They are also involved in the regulation of many processes, including hematopoiesis, the immune response and inflammation. IL-10 is one of the most important anti-inflammatory ...

OBJECTIVES The inflammatory response after cardiac surgery is characterized by a profound release of pro- and anti-inflammatory cytokines. Recent data suggest that the balance between pro- and anti-inflammatory cytokines is of greater importance than the absolute levels. Retransfusion of unwashed cardiotomy suction blood contributes to the inflammatory response, but the balance between pro- and...

t lymphocytes that are involved in cellular mediated immunity include two types known as tcd8+ (cytotoxic t lymphocytes) and tcd4+ (helper t lymphocytes). tcd4+ has four main subtypes, including th1, th2, th17, and treg lymphocytes.th17 lymphocytes play a role in defense against microbes that th1 and th2 lymphocytes have not the ability to respond to them. the most important cytokines, which ar...

Pain is a manifestation of rheumatoid arthritis (RA) that mediated by inflammatory and non-inflammatory mechanisms negatively affects quality life. Recent findings from Phase 3 clinical trial showed patients with RA who were treated Janus kinase 1 (Jak1) 2 (Jak2) inhibitor achieved significantly greater improvements in pain than those tumor necrosis factor blocker; both treatments resulted simi...

Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease that affects the epithelial lining of gastrointestinal tract. Recent single cell RNA-sequencing (scRNA-seq) studies suggested inflammation-associated fibroblasts (IAFs) play important roles in pathogenesis and drug resistance. To elucidate IAF’s role IBD, we isolated from patients with IBD profiled their responses to pa...

T lymphocytes that are involved in cellular mediated immunity include two types known as TCD8+ (Cytotoxic T lymphocytes) and TCD4+ (helper T lymphocytes). TCD4+ has four main subtypes, including TH1, TH2, TH17, and Treg Lymphocytes.TH17 lymphocytes play a role in defense against microbes that TH1 and TH2 lymphocytes have not the ability to respond to them. The most important cytokines, which ar...