As a kind of chronic inflammatory diseases, Rheumatoid arthritis (RA) has low cure rate and easy recurrence. It widely reported that abnormal activation mitogen-activated protein kinase (MAPK) nuclear factor kappa-B (NF-κB) signaling pathways are associated with the development RA inflammation. Blocking rheumatoid fibroblast-like synoviocytes (RA-FLS) can delay RA. Ononin is natural isoflavone ...

Osteoarthritis (OA) is a chronic degenerative joint disorder associated with pain and inflammation, the leading cause of disability worldwide. Owing to complexity OA inflammation driven by plethora inflammatory cytokines, current specific anti-cytokine therapies have not been successful. Among immune cells implicated in macrophages reportedly regulate via macrophage polarization. Given that pro...

Laser– assisted permanent hair removal iscommonly performed for the treatment of unwantedhair. This procedure is usually associated withpain and pain reduction has an important role inthe success of this treatment. A common methodof reducing pain is to use topical analgesics . Amixture of lidocaine and prilocaine (EMLA) is acommonly used and very effective topical anesthetic.Another agent is di...

Oregano (Origanum vulgare L.) is one of the most selled culinary and medicinal herb throughout the world. Flowering aerial parts and leaves of oregano have been used as a popular flavoring of food stuffs and as an antioxidant agent in cosmetics. Oregano contains a wide array of active components, including flavonoids, phenolic acids and glucosides, phenols and triterpenes. Several biological ac...

The inflammatory process involves increased vascular permeability, protein denaturation, and membrane alteration. Flavonoids are a class of secondary metabolites with biological pharmacological activities, including anti-inflammatory. bitter leaf, Vernonia amygdalina (VA), used in various alternative medicine several countries, Indonesia. Chemical components VA leaf polyphenolic compounds, flav...

Haemophilus parasuis (H. parasuis) is the causative agent of Glässer's disease, a severe membrane inflammation disorder. Previously we showed that Baicalin (BA) possesses anti-inflammatory effects via the NLRP3 inflammatory pathway in an LPS-challenged piglet model. However, whether BA has anti-inflammatory effects upon H. parasuis infection is still unclear. This study investigated the anti-in...

OBJECTIVE To study the anti-inflammatory and analgesic activities of diethyl 1,3-dicyclohexyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylate (ZL-5010) in vivo and in vitro. METHODS The analgesic effect of ZL-5010 was evaluated by acetic acid-induced writhing response in mice, and the anti-inflammatory effects was assessed in mice with xylene-induced ear edema and in rats with carrageenan-indu...

Myocardial dysfunction in sepsis has been linked to inflammation caused by pathogen-associated molecular patterns (PAMPs) as well as by host danger-associated molecular patterns (DAMPs). These include soluble heparan sulfate (HS), which triggers the devastating consequences of the pro-inflammatory cascades in severe sepsis and septic shock. Thus, there is increasing interest in the development ...

Isoniazid (INH) remains a cornerstone key constitute of the current tuberculosis management strategy, but its hepatotoxic potentiality remains a significant clinical problem. Our previous findings succeed to establish a rat model of INH hepatotoxicity employing the inflammatory stress theory in which non-injurious doses of inflammatory-mediating agent bacterial lipopolysaccharides (LPS) augment...