OBJECTIVES To describe the mode of presentation, interventions, and outcome of HIV infected patients with pulmonary embolism and a contraindication to anticoagulation, who were treated with a bird's nest filter. METHODS Retrospective review of case records and imaging department database at UCL Hospitals, London, UK. RESULTS Three patients had pulmonary embolism and contraindications to ant...

The records of 243 patients with Thompson prostheses for displaced femoral neck fractures have been studied. One hundred and seven prostheses were inserted through an anterior approach and 136 by a posterior approach. The short-term results and complications in these otherwise comparable groups are discussed. The infection rate of 18.5 percent in the group operated upon by the posterior approac...

A two-stage procedure was carried out on 57 patients with confirmed infection in a hip replacement. Allograft bone was used in the second stage. Pathogenic organisms were identified in all patients. In stage 1, the prosthesis was removed together with infected tissue. Antibiotics were added to customised cement beads. Systemic antibiotics were not used. At the second stage, 45 of the patients h...

We report a case of infected iliac artery aneurysm concomitant with liver abscesses caused by Fusobacterium nucleatum. A 58-year-old man developed an aneurysm of the right common iliac artery and liver abscesses. The aneurysm was resected and a femoro-femoral crossover bypass with a knitted Dacron graft was performed for impending rupture. Anaerobic cultures obtained from blood and intramural t...

OBJECTIVES To evaluate the activity of a new cephalosporin, ceftaroline, in comparison with other antistaphylococcal drugs (linezolid and vancomycin) at projected human therapeutic doses against methicillin-resistant Staphylococcus aureus (MRSA) and glycopeptide-intermediate S. aureus (GISA) strains. METHODS Using a rabbit experimental model of acute osteomyelitis, efficacy was assessed follo...

BACKGROUND Hematogenous osteomyelitis of long bone is rare in adults, especially in the immune competent host. Only a few cases have been described to date. OBJECTIVES To present a case series of femoral hematogenous osteomyelitis in adults, a rare condition that is difficult to diagnose and may cause major morbidity and mortality. METHODS We reviewed three cases of femoral hematogenous ost...

Although it has been established that myocyte enhancer factor 2 (MEF2) plays pivotal roles in the development of the cardiovascular system as well as skeletal muscle cells, little is known of its role in vascular inflammatory diseases such as atherosclerosis and restenosis after angioplasty. To investigate the role of MEF2 in vascular inflammation and that of p38 in the activation of MEF2, we i...

INTRODUCTION: Bone graft materials are placed in a variety of skeletal defects to promote bony union. Infection of bone graft devices are devastating complications that require multiple debridement surgeries, systemic antibiotic treatment, and may result in osseous non-union. Besides significant medical costs, there are also high costs from lost productivity and function. It is therefore critic...

introduction: pain control is the most important issue in emergency department management of patients with femoral bone fractures. the present study aimed to compare the procedural features of ultrasonography and nerve stimulator guided femoral nerve block in this regard. method: in this randomized clinical trial, patients with proximal femoral fractures presenting to emergency department were ...

PURPOSE To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. METHODS Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial lon- gitudinal incision was made and infected with different bacteria. RESULTS It is showed that 0.5 mg/kg/time of LPS p...