DNA array technology makes it possible to rapidly genotype individuals or quantify the expression of thousands of genes on a single filter or glass slide, and holds enormous potential in toxicologic applications. This potential led to a U.S. Environmental Protection Agency-sponsored workshop titled "Application of Microarrays to Toxicology" on 7-8 January 1999 in Research Triangle Park, North C...

If the classical paradigm of toxicology has been used for centuries, recent toxicological findings, soaring experimental costs and an increasing regulatory pressure have led the toxicology community towards mechanistic toxicology. This new area of research, focused on molecular envents underlying the toxicity of a chemical substance, motivates the emergence of new modelling approaches for toxic...

Inhalation Toxicology In article number 2100633 by Ajay Vikram Singh, Byung-Wook Park, and co-workers, a systematic approach is taken to discuss the bottleneck, pros cons of current technologies pertaining organ-on-a-chip systems for inhalation toxicology. Design processes inspired from soft robotics actuation with attention exposure, lung cells, materials used are presented.

The Asian Society of Toxicology (ASIATOX), which consists of the seven national toxicology member societies of Japan, Korea, China, Taiwan, Thailand, Singapore, and Iran, now boasts of more than 3,000 members from a variety of industries, academia, and regulatory organizations. ASIATOX congresses are spaced three years apart and rotated among the member societies. In 1995, ASIATOX joined the In...

Toxicology testing of fatally injured workers is not routinely conducted. We completed a case-series study of 2005-2009 occupational fatalities captured by Iowa's Fatality Assessment and Control Evaluation (FACE) Program. The goals of our research were to: (1) measure the proportion of FACE cases that undergo toxicology testing, and describe the factors associated with being tested, and (2) mea...

Background: Web of Science (WoS) is an online academic citation index provided by Thomson Reuters which supplies valuable bibliometric information for comparing impact of specific author, organization, or country in science production. The aim of this study was to compare toxicology publications of Iran and Turkey indexed in WoS from bibliometric point of view. Methods: The WoS database was ...

A great deal of toxicological and epidemiological data are available for asbestos and a wide variety of other mineral and manmade fibers. Experimental animal data suggest that certain fiber characteristics are responsible for observed biological effects such as cancer. An important fiber characteristic appears to be fiber size (length, diameter, aspect ratio); however, other characteristics suc...

background: malathion (mal) is a choice insecticide in the stored grain in different countries. the aim of the present study is to evaluate toxicological effects of 30-day intake of mal on the male reproductive system of wistar rats. methods: this research was ethically approved by the local authority at faculty of medicine, monastir, tunisia. three mal treated groups received 1 ml corn oil con...

introduction: chlorpyrifos (cpf), an organophosphate insecticide, was evaluated for potential teratogenic effects in mice. a single oral dose of insecticide (i.e. 72, 36 18 or 9 mg/kg) was given to the pregnant females on gestation day6 (gd6). these doses correspond 50, 25, 12.5 and 6.25% to the calculated ld50 value (144 mg/kg) for the pregnant mice. no signs of overt toxicity were observed at...