The USP has proposed using inductively coupled plasma (ICP) for determining heavy metals in drug articles to replace the USP <231> heavy metals test. While the current USP <231> procedure will detect Pb, Hg, Bi, As, Sb, Sn, Cd, Ag, Cu and Mo, the proposed method will test for Al, Sb, As, Be, B, Cd, Cr, Co, Cu, In, Ir, Fe, Pb, Li, Mg, Mn, Hg, Mo, Ni, Os, Pd, Pt, Rh, Rb, Ru, Se, Sr, Tl, Sn, W and...

An informative analytical method, based on commercially available capillary electrophoresis (CE), inductively coupled plasma mass spectrometry (ICP-MS) and interface units, was developed for ascertaining possible metabolic transformations of metal-based drugs. Using a novel anticancer gallium compound, it was demonstrated that the drug remains intact in the simulated intestine juice. On the con...

Different polytypes (α-SiC and β-SiC) and crystallographic orientations ((0001) and (11-20) of 6H-SiC) have been used in order to elaborate Silicon Carbide (SiC) nanopillars using inductively coupled plasma etching method. The cross section of the SiC pillars shows a rhombus, pentagon, or hexagonal morphology depending on polytypes and crystallographic orientations. The favored morphologies of ...

Gold compounds are among the few therapeutic agents that can cause remission of aggressive rheumatoid arthritis. Although the mechanism for their toxicity and efficacy is unknown, gold levels in blood have been emphasized recently. In this report, we describe a systematic method to study the gold interaction with red blood cells and its distribution in the cell. Flow injection analysis (FIA) an...

We investigated the performance of nitrogen microwave inductively coupled atmospheric-pressure plasma mass spectrometry (MICAP-MS) under matrix effects and its applicability to trace element analysis in steels.

A simple and rapid method for the determination of 137Ba isotope abundances in water samples by inductively coupled plasma-optical emission spectrometry (ICP-OES) coupled with least-squares support vector machine regression (LS-SVM) is reported. By evaluation of emission lines of barium, it was found that the emission line at 493.408 nm provides the best results for the determination...

The synthesis and analysis of inorganic material combinatorial libraries by a directed-sorting, split-pool bead method was demonstrated. Directed-sorting, split-pool, metal-loaded libraries were synthesized by adsorbing metal salts (H2PtCl6, SnCl2, CuCl2, and NiCl2) and metal standards (Pt, Cu, Ni in HCl) onto 2-mg porous gamma-alumina beads in 96- or 384-well plates. A matrix algorithm for the...

The inductively coupled RF discharge is known to exhibit two modes of operation depending on the level of incident power. Dominant capacitive coupling (E-mode discharge) occurs at low-power level while at high power, dominant inductive coupling (H-mode discharge) is obtained. In this work, we investigate the characteristics of the E-mode and H-mode discharges generated in a planar coil inductiv...

BACKGROUND Boron neutron-capture therapy (BNCT) is a drug-targeted binary radiotherapy for cancer. The (10)B capture of thermal neutrons induces secondary radiation within cells during irradiation. The most widely used boron carrier is 4-dihydroxyborylphenylalanine (BPA). The duration and timing of the irradiation is adjusted by monitoring (10)B concentrations in whole blood. METHODS We devel...