Background: Pemphigus vulgaris, the most common form of pemphigus, is due to the production of auto-antibodies directed against adhesion molecules (desmoglein 1 and 3) that belong to the cadherin family. B cell-activating factor of the TNF family (BAFF) and a proliferation-inducing ligand (APRIL) may play a significant role in autoimmune diseases such as pemphigus vulgaris. Only a few studies h...

Abstract Roots provide the plant with water and nutrients anchor it in a substrate. Root development is controlled by hormones various sets of transcription factors. Recently, small peptides their cognate receptors have been identified as controlling root development. Small bind to membrane-localized receptor-like kinases, inducing dimerization co-receptor proteins for signaling activation givi...

Protein crystalline frameworks are attractive for biomimetic and nanotechnological studies because they could augment the useful functionalities of numerous proteins through dense packing and uniform orientation. However, their formation and precise structural control is challenging. Here we present novel protein crystalline frameworks with controllable interpenetration. The homotetrameric lect...

The small molecule 4EGI-1 was identified as an inhibitor of cap-dependent translation initiation owing to its disruption of the eIF4E/eIF4G association through binding to eIF4E. 4EGI-1 exhibits growth-inhibitory and apoptosis-inducing activity in cancer cells; thus, we were interested in its therapeutic efficacy in human lung cancer cells. 4EGI-1, as a single agent, inhibited the growth and ind...

Colloidal quantum dots (CQDs) are free-standing nanostructures with chemically tunable electronic properties. This combination of properties offers intriguing new possibilities for nanoelectromechanical devices that were not explored yet. In this work, we consider a new scanning tunneling microscopy setup for measuring ligand-mediated effective interdot forces and for inducing motion of individ...