Nitric oxide has been shown to have important physiological regulatory roles, i. e, vasodilation, neurotransmitter release, etc. Now, we review its role as an antibacterial and antiviral agent. Nitric oxide has also been identified as an important factor in the development of non-specific immunity. And accordingly, nitric oxide synthase (NOS), the catalytic enzyme producing nitric oxide, is a k...

Fanconi anemia complementation group C (Fancc)-deficient murine bone marrow progenitors demonstrate increased sensitivity to growth inhibition by interferon gamma (IFNgamma), tumor necrosis factor alpha (TNFalpha), and macrophage inflammatory protein 1alpha (MIP-1alpha). This property has been proposed as a possible pathogenic factor in the marrow failure seen in Fanconi anemia. Supporting our ...

This study was conducted to investigate effects of vitamin A (VA) and K3 (VK3) on immune function intestinal antioxidant capacity aged laying hens. In a 3 × factorial arrangement, the diets 1080 Roman Pink hens (87 weeks old) formulated with deficient, adequate excess VA VK3, including 0, 7000 14000 IU/kg 2.0 4.0 mg/kg VK3 for 8 weeks. Interactive between were observed that decreased splenetic ...

Inhaled nitric oxide is a selective pulmonary vasodilator used for the treatment of pulmonary hypertension. The potential adverse effects of inhaled nitric oxide are unknown and represent the focus of the present studies. Whereas inhalation of nitric oxide (10 to 100 ppm, 5 h) by Balb/c mice had no effect on the number or type of cells recovered from the lung, a dose-related increase in broncho...

background and objective: alzheimer’s disease (ad) is a neurodegenerative disorder specified by deposition of b-amyloid (ab) and neuronal loss that leads to learning and memory disturbances. one of the most important causes of ad is glutamate-dependent excitotoxicity in brain regions that is vulnerable to ad. according to previous reported results, it was revealed that riluzole, as a glutamate ...

During infection and inflammation, bacterial and inflammatory proteases break down extracellular matrices into macromolecular fragments. Fibronectin fragments are associated with disease severity in arthritis and periodontitis. The mechanisms by which these fragments contribute to disease pathogenesis are unclear. One likely mechanism is that fibronectin fragments induce apoptosis of resident c...

Submit Manuscript | http://medcraveonline.com Abbreviations: NF-κB: Nuclear Factor Kappa-Light-ChainEnhancer of Activated B Cells; NO: Nitric Qxide; TNF-α: Tumor Necrosis Factor α; IL-1β: Interleukin-1β; RA: Rheumatoid Arthritis; IBD: Inflammatory Bowel Disease; COPD: Chronic Obstructive Pulmonary Disease; IKK-1: Inhibitor of Kappa B Kinase; ROS: Reactive Oxygen Species; INOS: Inducible Nitric ...

Introduction: Neurodegeneration is a process that is characterized by the loss of neuronal structure and function and eventually ends with neuronal death. An elevated level of inducible nitric oxide synthase (iNOS) is suggested to accompany this process by inducing oxidative and nitrosative damage. Vitamin D is reported to protect glial cells against neurotoxicity via suppressing iNOS synthesis...

Endothelial nitric oxide synthase (eNOS) is the only NOS isoform expressed in normal coronary arteries. However, all 3 NOS isoforms—eNOS, inducible NOS (iNOS), and neuronal NOS (nNOS)—are found in human atherosclerotic plaques.1 Precise studies of knockout mice have uncovered the role of eNOS and iNOS in atherogenesis (Figure). The eNOS isoform protects against atherosclerosis, because mice lac...