Gastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was cond...

The study was designed to determine the gastroprotective and ulcer healing efficacy of basic transforming growth factor (bFGF) and to assess whether this peptide contributes to the action of sucralfate on the rat stomach. Application of human recombinant bFGF (1-100 micrograms/kg/hour subcutaneously) failed to affect the formation of acute gastric lesions induced by 100% ethanol and acidified a...

Abstract Background Combretum paniculatum (Combretaceae) Vent. is commonly used in traditional medicine to treat ulcers and gastrointestinal disorders, including distended spleens the liver. This study investigated gastroprotective effects of C. leaf extract its fractions on absolute ethanol-induced gastric rats explored their endogenous antioxidant (SOD, MDA, GSH, Catalase) levels. Butanol, n-...

Peptic ulcer disease is a gastrointestinal disorder of high mortality and morbidity. Therapy this condition with conventional drugs presents therapeutic challenge due to incidents unwanted side effects, the cost these medications. The use products from natural sources will provide useful alternatives their minimal being inexpensive, readily available, especially in resource-challenged nations c...

1Dr R P Center of Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Corresponding Author : Prof. Namrata Sharma, E-mail: [email protected] Received on : 08/10/2016, Revision accepted on : 18/11/2016 Conflict of Interest : None, Financial Disclosure : None © Current Indian Eye Research. A corneal ulcer is defined as loss of surface corneal epithelium along wi...

BACKGROUND Diabetes mellitus is an independent risk factor for impaired healing of peptic ulcers, and there are currently no supplementary therapeutics other than the standard antipeptic medicine to improve the ulcer healing in diabetes. This study examined the potential pleiotropic effect of a glucagon-like peptide (Glp)-1 analogue exendin (Ex)-4 on the regeneration of gastric ulcer in strepto...