During sepsis, bacterial products, particularly LPS, trigger injury in organs such as the liver. This common condition remains largely untreatable, in part due to a lack of understanding of how high concentrations of LPS cause cellular injury. In the liver, the lysosomal degradative pathway of autophagy performs essential hepatoprotective functions and is induced by LPS. We, therefore, examined...

Liver fibrosis results from many chronic injuries and may often progress to cirrhosis hepatocellular carcinoma (HCC). In fact, up 90% of HCC arise in a cirrhotic liver. Conversely, stress is implicated liver damage, worsening disease outcome. Hence, could play role disrupting homeostasis, concept that has not been fully explored. Here, murine model TAA-induced we identified nerve growth factor ...

The immune system is alerted to cell death by molecules known as damage-associated molecular patterns (DAMPs). These molecules partly mediate acetaminophen-induced liver injury, an archetypal experimental model of sterile cell death and the commonest cause of acute liver failure in the western world. Cyclophilin A (CypA) is an intracellular protein that is proinflammatory when released by cells...

objective(s): 3,4-methylenedioxymethamphetamine (mdma) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce apoptosis in  liver cells. the present study aimed to investigate the effects of pentoxifylline (ptx) on liver damage induced by acute administration of mdma in wistar rat. materials and methods: animals were administered with...

Alcoholic liver disease (ALD) is an important worldwide public health issue with no satisfying treatment available since now. Here we explore the effects of recombinant human cytoglobin (rhCygb) on chronic alcohol-induced liver injury and the underlying mechanisms. In vivo studies showed that rhCygb was able to ameliorate alcohol-induced liver injury, significantly reversed increased serum inde...

The in vivo hepatoprotective activity of Homalomena aromatica was evaluated carbon tetrachloride-induced hepatic injury model Swiss albino mice. Effects the methanolic rhizome extracts (HAME) at a dose 200 mg/kg body weight and 500 tested for its efficacy on CCl4 (1ml/kg weight) induced liver injury. Hepatic toxicity enzyme markers histological parameters were studied. Daily oral administration...

t-2 toxin, a trichothecene mycotoxin, is considered to be one of the most toxic compounds that are produced by molds, particularly the fusarium species. fusarium species have been recognized as a great agricultural problem. they occur worldwide on a variety of plant hosts and cereal grains. the aim of this study was to investigate t-2 toxin-induced liver injury using in situ perfused rat liver....

In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

Wei HR, Wei H, Wang H, Tian Z, Sun R. Activation of natural killer cells inhibits liver regeneration in toxin-induced liver injury model in mice via a tumor necrosis factor-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 299: G275–G282, 2010. First published May 6, 2010; doi:10.1152/ajpgi.00026.2010.—Liver lymphocytes are enriched in natural killer (NK) cells, and activation of NK ...

background there is still no suitable mice model that can completely mimic the human fulminant hepatitis, which sets a block for drug effect evaluation and mechanism researching of human fulminant hepatitis. objectives the aim of this study was to establish an animal model able to mimic the main features of human fulminant hepatitis. materials and methods dimethylnitrosamine (dmn) was peritonea...