Indomethacin is a widely used nonsteroidal anti-inflammatory drug. We studied the human cytochrome P450 (CYP) isoform responsible for indomethacin O-demethylation, the major metabolic pathway for indomethacin. For indomethacin O-demethylase activities, the KM value was 34.6 +/- 5.4 muM and the Vmax value was 14.1 +/- 3.9 pmol/mg/min in human liver microsomes (N = 4). Indomethacin O-demethylase ...

AIMS We investigated the effect of several Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), on the preoptic nerve oxygen tension (ONPO2), as indomethacin previously has demonstrated a strong decreasing effect on ONPO2. We tested whether these NSAIDs, like indomethacin, also reduce the increasing effect of dorzolamide on ONPO2. METHODS ONPO2 was measured 0.5 mm above the optic disc in 23 domest...

Aim. The side effects associated with the use of indometacin are noted by about 30-60% patients, therefore, in this context problem adverse event rate reduction is still relevant today. Cryopreserved placental extract (CEP) attracted our attention as a means pathogenetic correction ulcerogenic action indomethacin. aim paper to characterize antiulcer activity cryopreserved placenta on model indo...

BACKGROUND Tissue damage caused by surgical procedures nearly always results in pain. The effective management of postoperative pain remains a challenge because of its influence on the surgical outcome and its critical role in early mobilization and functionality. Recent research on postoperative pain management supports a treatment approach known as "multimodal analgesia," which comprises the ...

37 febrile children aged between 3 months and 6 years were treated with paracetamol in a dose of 15--20 mg/kg by either oral elixir or rectal suppository. The rectal route was found to have an equal antipyretic effect and offers a practical alternative in those children for whom the oral route is not possible.20

OBJECTIVE The objective of this study was to evaluate the extent of renal adverse effects caused by ibuprofen or indomethacin in order to choose the safer drug to administer to preterm infants. METHODS THE FOLLOWING THREE PARAMETERS OF RENAL FUNCTION WERE TAKEN INTO CONSIDERATION: 1) the urine output; 2) the serum creatinine concentration; and 3) the frequency of oliguria. The bibliographic s...

PURPOSE There has been an ongoing increase in the frequency and severity of blunt chest injuries. Their rather high lethality is caused by the injury alone as well as by the following systemic inflammatory response. The aim of the study is to verify the efficacy of the pharmacological blockade of the systemic inflammatory response syndrome (SIRS) in serious blunt chest injuries, and to identify...

Let Tt = e−tL be a semigroup of self-adjoint linear operators acting on L(X,μ), where (X, d, μ) is a space of homogeneous type. We assume that Tt has an integral kernel Tt(x, y) which satisfies the upper and lower Gaussian bounds: C1 μ(B(x, √ t)) exp ( −c1d(x, y)/t ) ≤ Tt(x, y) ≤ C2 μ(B(x, √ t)) exp ( −c2d(x, y)/t ) . By definition, f belongs to H L if ‖f‖H1 L = ‖ supt>0 |Ttf(x)|‖L1(X,μ) < ∞. W...

In this study, we examined the effect of nimesulide and ranitidine on the indomethacin- and ibuprofen-induced ulcer. In addition, we investigated whether there was a direct chemical interaction of nimesulide and ranitidine with indomethacin, and also whether nimesulide and ranitidine neutralized the gastric acid in vitro. Our studies showed that nimesulide (100, 300, 500 mg/kg) prevented the in...