Abstract Introduction Clinicians prescribing hypnotics remain concerned regarding the inability to discontinue after chronic use. In a controlled prospective study using self-administration choice procedures we tested whether BZRA hypnotic receptor specificity is predictive of discontinuation difficulty in clinical trial which insomnia subjects are instructed stop taking their medication 6 mont...

The most well-established finding gleaned from decades of experimental hypnosis research is that individuals display marked variability in responsiveness to hypnotic suggestions. Insofar as this va...

Dr. Lynn reports some second thoughts about an article he published in 1994, in which he described the use of a high hypnotizable/simulator design to study hypnotic dream and hidden observer reports. He found that despite some overlap between highand lowhypnotizable simulators, high hypnotizables reported more primary process material in hypnotic dream reports. He also describes two highly effe...

The hangover effects of 768 mg chlormethiazole, an hypnotic with a half-life of approximately 4 hr, were compared with those of placebo in a double-blind cross-over study in 8 young subjects. Ten hours after dosing there were no differences between the preparations in the subjects' psychomotor performance, EEG sleep scores, or visual analogue ratings. Thus, an hypnotic which is rapidly removed ...

This review explores basic sleep physiology, the mechanism of action for each class of hypnotic agents, their clinical application based on pharmacodynamic and pharmacokinetic factors, and potential pharmacologic sleep-inducing mechanisms of future hypnotics. The paper challenges the reader to understand the neuroscientific basis of insomnia and use this knowledge to guide prescription of hypno...