AIMS Raloxifene treatment of osteoporotic fractures is clinically effective, but economic evidence in support of raloxifene reimbursement is lacking in the People's Republic of China. We aimed at evaluating the cost-effectiveness of raloxifene in the treatment of osteoporotic fractures using an osteoporosis health economic model. We also assessed the impact of medication persistence and adheren...

2. A decision analytic framework and a societal perspective were adopted. The least costly and non-dominated strategy was H pylori serologic testing, followed by treating those positive for H pylori, with no follow-up testing. Its incremental cost-effectiveness ratio was US$20 547 for men and HK$26 840 for women per life year saved or Cost-effectiveness of Helicobacter pylori screening and trea...

BACKGROUND New biologic therapies are available for moderate to severe psoriasis. OBJECTIVE To determine the most cost-effective sequence of biologic treatments. METHODS Through modeling of the clinical pathway of biologic agents, adalimumab, alefacept, efalizumab, etanercept, and infliximab, the costs and benefits (quality-adjusted life-years [QALYs]) were determined. A decision rule deter...

of ischemic stroke moderate and severe degrees of severity using a drug cerebrolysin compared with standard therapy, cost-effectiveness ratios (CER) were obtained 419656 RUB (6920 EUR) and 563183 RUB (9287 EUR), respectively. ConClusions: The standard therapy in combination with drug cerebrolysin has a lower CER compared with standard therapy, therefore, it is a dominant technology from the per...

BACKGROUND To evaluate the various treatments for patients with hormone-refractory prostate cancer with bone metastases using a Markov model. METHODS AND MATERIALS The base case to be evaluated was of a man with hormone-refractory prostate cancer. The evaluated palliative treatments were pain medication only, chemotherapy consisting of mitoxantrone and prednisone, and single- and multifractio...

Five percent of all pregnant women and 25% of pregnant women with insulin-dependent diabetes mellitus (IDDM) develop postpartum thyroiditis (PPT) during the first year after delivery. PPT has significant morbidity and can be predicted prenatally by the presence of thyroid peroxidase (TPO) antibody. Our objective was to estimate the cost-effectiveness of screening pregnant women for the TPO anti...

Interest is growing in the application of standard statistical inferential techniques to the calculation of cost-effectiveness ratios (CER), but individual level data will not be available in many cases because it is very difficult to undertake prospective controlled trials of many public health interventions. We propose the application of probabilistic uncertainty analysis using Monte Carlo si...

Incremental or marginal cost-effectiveness ratios are founded on a number of assumptions that weaken their suitability as a way to balance competing economic and clinical priorities. We therefore propose a more relevant and responsible way to gauge the impact of clinical management strategies based on “consumer protection” principles—explicit disclosure of (1) the total magnitude of expected be...

OBJECTIVE To assess the cost-effectiveness of community-based practitioner programmes in Ethiopia, Indonesia and Kenya. METHODS Incremental cost-effectiveness ratios for the three programmes were estimated from a government perspective. Cost data were collected for 2012. Life years gained were estimated based on coverage of reproductive, maternal, neonatal and child health services. For Ethio...

OBJECTIVE To investigate whether a single optimal vaccination strategy exists across countries to deal with a future influenza pandemic by comparing the cost effectiveness of different strategies in various pandemic scenarios for three European countries. DESIGN Economic and epidemic modelling study. SETTINGS General populations in Germany, the Netherlands, and the United Kingdom. DATA SO...