نتایج جستجو برای: in silico modeling

تعداد نتایج: 17058751  

2015
Nicolo Fusi Ian Smith John Doench Jennifer Listgarten

The CRISPR/Cas9 system provides unprecedented genome editing capabilities; however, several facets of this system are under investigation for further characterization and optimization, including the choice of guide RNA that directs Cas9 to target DNA. In particular, given that one would like to target the proteincoding region of a gene, hundreds of guides satisfy the basic constraints of the CR...

2017
Amy Marshall-Colon Stephen P. Long Douglas K. Allen Gabrielle Allen Daniel A. Beard Bedrich Benes Susanne von Caemmerer A. J. Christensen Donna J. Cox John C. Hart Peter M. Hirst Kavya Kannan Daniel S. Katz Jonathan P. Lynch Andrew J. Millar Balaji Panneerselvam Nathan D. Price Przemyslaw Prusinkiewicz David Raila Rachel G. Shekar Stuti Shrivastava Diwakar Shukla Venkatraman Srinivasan Mark Stitt Matthew J. Turk Eberhard O. Voit Yu Wang Xinyou Yin Xin-Guang Zhu

Multi-scale models can facilitate whole plant simulations by linking gene networks, protein synthesis, metabolic pathways, physiology, and growth. Whole plant models can be further integrated with ecosystem, weather, and climate models to predict how various interactions respond to environmental perturbations. These models have the potential to fill in missing mechanistic details and generate n...

Journal: :Biochemical and Biophysical Research Communications 2018

Journal: :World Journal of Biology Pharmacy and Health Sciences 2023

This study developed an antibacterial oral gel to inhibit Streptococcus mutans, a bacterium that causes tooth decay. The was formulated using methanol extract of Piper betel leaves, hydroxypropyl methylcellulose and glycerin at different concentrations. evaluated for pH, viscosity activity against S. mutans standard methods. showed potent activity, supporting its use in the formulation. In sili...

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