Two important features of amphibian metamorphosis are the sequential response of tissues to different concentrations of thyroid hormone (TH) and the development of the negative feedback loop between the pituitary and the thyroid gland that regulates TH synthesis by the thyroid gland. At the climax of metamorphosis in Xenopus laevis (when the TH level is highest), the ratio of the circulating pr...

Larval sea lampreys (Petromyzon marinus) were exposed to either a warm (18 degrees C) or a cold (3 degrees C) water temperature and either with (treated) or without (untreated) the presence of potassium perchlorate (KClO4). After 23 weeks, larvae were examined for signs of metamorphosis and serum samples were collected to assay thyroxine (T4) and 3,5,3'-triiodothyronine (T3) concentrations. Wat...

Craniofacial remodeling during flatfish metamorphosis, including eye migration, is perhaps the most striking example of asymmetric postembryonic development in the vertebrate world. The asymmetry of the cranium mainly results from distortion of the frontal bones, which depends on eye migration during metamorphosis. However, it is unclear how the up-migrating eye causes distortion of the frontal...

Diverse animal taxa metamorphose between larval and juvenile phases in response to bacteria. Although bacteria-induced metamorphosis is widespread among metazoans, little is known about the molecular changes that occur in the animal upon stimulation by bacteria. Larvae of the tubeworm Hydroides elegans metamorphose in response to surface-bound Pseudoalteromonas luteoviolacea bacteria, producing...

Son yıllarda bilim insanları tarafından bir anlam oluşturma aracı olarak sıklıkla kullanılan metaforlar, insanların geçmiş bilgi birikimi ve deneyimleri ile geliştirdikleri etiketlerle gerçekliği nasıl inşa ettiklerini anlamaya yaramaktadır. Bu araştırma, Jandarma subay adayları subayların düşünce derinliklerinde “Jandarma” kavramını algıladıklarını metaforlar yoluyla belirlemek amacıyla yapılm...

Mechanisms by which attainment of specific body sizes trigger developmental transitions to adulthood (e.g. puberty or metamorphosis) are incompletely understood. In Drosophila, metamorphosis is triggered by ecdysone synthesis from the prothoracic gland (PG), whereas growth rate is increased by insulin/insulin growth factor signalling (IIS). Transgene-induced activation of PI3K, the major effect...

Teleosts are the largest and most diverse group of vertebrates, and many species undergo morphological, physiological, and behavioral transitions, "metamorphoses," as they progress between morphologically divergent life stages. The larval metamorphosis that generally occurs as teleosts mature from larva to juvenile involves the loss of embryo-specific features, the development of new adult feat...

Flatfish is famous for the asymmetric transformation during metamorphosis. The molecular mechanism behind the asymmetric development has been speculated over a century and is still not well understood. To date, none of the metamorphosis-related genes has been identified in flatfish. As the first step to screen metamorphosis-related gene, we constructed a whole-body cDNA library and a whole-body...