BACKGROUND T cell-mediated immune responses contribute to the hepatocellular injury during autoimmune hepatitis, viral infection, and hepatotoxins. Pharmacological compounds regulating immune responses are suitable candidates for prevention/treatment of this pathology. Therefore, the main aim of this study was to define the effects of antioxidant, anti-inflammatory mixture of citrus peel extrac...

conclusions acute hev infection shows a pattern of th1-type immune response, and the direct significant positive correlation between the serum level of scd26 and ifn-γ in acute hev infected patients, suggests that the trend of scd26 levels is a valuable marker for predicting hepatic inflammation in hepatitis e. results the results showed a significant difference in ifn-γ and scd26 (p < 0.0001 a...

background: triple-course vaccination against hepatitis b might sometimes fail to increase antibody titers or maintain it at sufficient levels. the aim of this study was to evaluate the rate of seroprotection in dental students after receiving recombinant hepatitis b vaccine.     methods: anti-hbs levels of 124 dental students who had received triple-course hepatitis b vaccines (scheduled at mo...

background hepatitis c virus (hcv) infection has been explained as a disease that sometimes present with rheumatic manifestations indistinguishable from rheumatoid arthritis. this study has been performed to evaluate the frequency of hepatitis c virus infection in a group of patients with rheumatoid arthritis. patients and methods in this study, during one year, serum samples collected from two...

Immune-related hepatitis (irH) is a fairly frequent complication of immune checkpoint inhibitors (ICIs). Its management generally based on withholding ICIs and the rapid initiation corticosteroids, which successful in 63 to 96% cases. Mycofenolate mofetil (MMF) accepted as second-line immunosuppressant case failure corticosteroids. In rare cases, though, irH also resistant MMF may lead liver fa...

The adaptive immune system, including type1 helper T cells (Th1 cells), cytotoxic T lymphocytes (CTLs), and dendritic cells (DCs), plays an important role in the control of hepatitis B virus (HBV). On the other hand, regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) suppress the immune reaction in HBV and hepatocellular carcinoma (HCC). Excessive activation of immune suppr...

The association between the hepatitis C virus and B-cell non-Hodgkin’s lymphomas is controversial. We review the epidemiological evidence behind the association, and look at the reasons behind the variation in study findings. There is increasing evidence of the pathogenesis of hepatitis C-associated lymphoma. Treatment of the hepatitis C virus with antiviral therapy may lead to the regression o...

The association between the hepatitis C virus and B-cell non-Hodgkin's lymphomas is controversial. We review the epidemiological evidence behind the association, and look at the reasons behind the variation in study findings. There is increasing evidence of the pathogenesis of hepatitis C-associated lymphoma. Treatment of the hepatitis C virus with antiviral therapy may lead to the regression o...

OBJECTIVES To determine if the Advisory Committee on Immunization Practices hepatitis B screening, vaccination, and prophylaxis recommendations were being followed in North Carolina, and to establish a baseline hepatitis B seroprevalence rate. DESIGN A survey of mother and infant birthing facility medical records. SETTING Four birthing facilities selected from each of the 7 districts in Nor...

The recent addition of testing volunteer blood donors for antibody to hepatitis B core antigen (anti-HBc) has raised questions not apparent when such testing is applied to hepatitis B (HB) infected patients. The review of published studies, and our own, demonstrates that it is difficult to evaluate false positive results. Some patients appear to lose antibody to hepatitis B surface antigen (ant...