Herpes simplex virus type 2 (HSV-2) infections are frequent in HIV (human immunodeficiency virus) infected patients. In those cases, genital herpes may have an atypical clinical presentation. Hypertrophic and vegetating variants are unusual. The authors describe a case of hypertrophic perianal herpes in an HIV patient with unsatisfactory response to acyclovir and valacyclovir, successfully trea...

Simultaneous or sequential, planned administration of ipilimumab could significantly enhance the antitumor effects of nivolumab in advanced melanoma patients. On the other hand, the efficacy of ipilimumab for nivolumab-resistant advanced melanoma is extremely poor. Therefore, additional supportive therapy for anti-PD-1 antibody therapy-resistant advanced melanoma has been widely investigated. I...

Method: This is a prospective, randomized, open trial study (from Iran) from September 2008 to September 2010, including 50 patients (25 patients in the combined imiquimod and cryotherapy group and 25 patients in the intralesional MA group). Patients were randomly assigned to receive combined cryotherapy biweekly with imiquimod three times per week or intralesional MA weekly until complete cure...

© 2012 The Authors. doi: 10.2340/00015555-1166 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Imiquimod (AldaraTM, 3M Pharmaceuticals) is a member of the imidazoquinolone family of drugs. It is a topical treatment approved by the US Food and Drug Administration (FDA) for the treatment of external genital and perianal warts, non-hypertrophic actinic keratoses in immunocomp...

Non-keratinocyte cutaneous malignancies including breast cancer metastasis and melanoma in situ are often poor surgical candidates due to their anatomical location, size the morbidities associated with surgery. Imiquimod, a toll-like receptor 7 agonist, is used for treatment of these malignancies, which activates innate immunity skin. However, imiquimod’s modest effect on activation adaptive li...


 Psoriasis is a chronic, inflammatory condition that primarily affects the skin, hair, and joints associated with significant humanistic economic consequences. was induced in mice this work using an imiquimod 5% cream, immune response modifier can cause psoriasis-like skin inflammation when given orally. Paquinimod prepared as suspension has been orally to before application. The current ...