Imidazoles and their derivatives are compounds with chemotherapeutic applications. In this study, we investigated the chemical functionalization of carboxylated multiwalled carbon nanotubes (MWNT-COOH) by 1,2-phenylendiamine. Multiwalled nanotube (MWNT)-benzimidazole was obtained by an MWNT-amide reaction with POCl(3) after 72 hours, which was confirmed by Fourier transform infrared, scanning e...

A series of 1-substituted 2, 4, 5 triphenyl imidazoles were synthesized by the reaction equimolar mixture of 2, 4, 5 triphenyl imidazole with chloro compound in the presence of anhydrous potassium carbonate. The newly synthesized compounds were characterized on the basis of UV, IR and H NMR spectra. The synthesized compounds were screened for antiinflammatory, antimicrobial activities. Antiinfl...

Vulvo-vaginal candidiasis (VVC) is a common infection among women. 5-8% of women with acute infection experience recurrent vulvo-vaginal candidiasis (RVVC). There is currently no gold standard treatment for RVVC. Although antifungal agents such as imidazoles have been successfully used as first-line treatment for acute VVC, the effectiveness of these medications is limited for RVVC, and various...

Dear Editor, Acanthamoeba species are opportunistic pathogens that can cause life-threatening diseases in the immunocompromised host. In healthy individuals, Acanthamoeba can cause ulcerating keratitis, which is associated with the use of improperly sterilised contact lenses, trauma or washing with contaminated water.1 Reports have shown that the defenses of a healthy host seemed sufficient to ...

vascular response to endotoxin in intact dogs. Surgery. 73: 246-255 Puig-Muset P, Puig-Parellada P, Martin-Esteve J (1972) Biochemical and Pharmacological Aspects of Imidazole. Barcelona, Spain, published by the authors, pp 99-101 Samuelsson B, Goldyne M, Granstrom E, Hamberg M, Hammarstrom S, Malmsten C (1978) Prostaglandins and thromboxanes. Annu Rev Biochem 47: 997-1029 Webb JG, Saelens DA, ...

Management of fungal infections is complex with increasing choice of antifungals. Mortality and morbidity are significant despite treatment. Azoles are commonly used compounds which inhibit fungal lanosterol 14 demethylase, thereby depleting ergosterol in the fungal cell membrane with the accumulation of lanosterol precursors. Imidazoles (miconazole, ketoconazole, clotrimazole) are used in topi...

common to both these compounds (Heath & Wildy, 1956a, b). These results indicated that this fungus forms ergothioneine by methylation and sulphuration of histidine. Subsequent work (Wildy & Heath, 1956, 1957) revealed that [2(ring)-14C]histamine would not serve as a precursor of the imidazole nucleus of either histidine or ergothioneine. Various metabolites of histamine, imidazoles possessing m...