The serine/cysteine protease inhibitor SCCA1 (SERPINB3) is upregulated in many advanced cancers with poor prognosis, but there is limited information about whether it makes functional contributions to malignancy. Here, we show that SCCA1 expression promoted oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and that SCCA1 silencing in breast cancer...

background: approximately 10-14% of the clinically acknowledged pregnancies end with spontaneous abortion at caucasian population. possible immunologic causes of recurrent miscarriages have been extensively researched. the change in the cytokines balance synthesis in favor of those synthesized by th2 cells with an increase of interleukin 6 (il6) and interleukin10 (il10) secretion is considered ...

background: the purpose of the present study was to compare the serum levels of il6 and ca125 in women with and without endometriosis. they were also compared in mild, moderate and severe cases. methods: in this case-control study, ca125 and il6 levels in 76 women with laparoscopic proven endometriosis were compared with 76 women without evidence of endometriosis. sensitivity, specificity, posi...

BACKGROUND The clinical management of leprosy Type 1 (T1R) and Type 2 (T2R) reactions pose challenges mainly because they can cause severe nerve injury and disability. No laboratory test or marker is available for the diagnosis or prognosis of leprosy reactions. This study simultaneously screened plasma factors to identify circulating biomarkers associated with leprosy T1R and T2R among patient...

Purpose: The aim of this study is to see oxidative DNA damage (8-OHdG), its relationship with inflammatory mediators (IL6 and TNFA), reflections on laboratory findings in patients who had COVID-19 infection at different intensities.
 Materials Methods: Serum interleukin-6 (IL6), tumor necrosis factor-alpha (TNFA), 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels were measured using kits based t...

Background: Giant cell arteritis (GCA) is the most frequent form of systemic vasculitis affecting temporal artery (TA) and aorta. Macrophages T cells are well recognized players in pathogenesis GCA while B often not taken into account. Recently, changes circulating compartment were documented found to organize tertiary lymphoid organs at site vascular inflammation (TA aorta). 1,2 The exact role...

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor produced by mesenchymal and myeloid cells following activation by inflammatory stimuli. It has previously been shown that a region of the G-CSF promoter, (-200 to -165) containing the decanucleotide CK-1 element and two repeated sequences that resemble nuclear factor (NF)-interleukin-6 (IL-6) binding sites, is requir...