Hernandez-Valladares M, Rihet P, Iraqi FA. Host susceptibility to malaria in human and mice: compatible approaches to identify potential resistant genes. Physiol Genomics 46: 1–16, 2014. First published October 29, 2013; doi:10.1152/physiolgenomics.00044.2013.—There is growing evidence for human genetic factors controlling the outcome of malaria infection, while molecular basis of this genetic ...

Diabetic neuropathy (DN) is one of the most frequent and troublesome complications of diabetes mellitus. Evidence from diabetic animal models and diabetic patients suggests that reduced availability of neuroprotective and pro-angiogenic factors in the nerves in combination with a chronic pro-inflammatory microenvironment and high level of oxidative stress, contribute to the pathogenesis of DN. ...

BACKGROUND Th2 cytokine responses are enhanced by all trans retinoic acid (ATRA), the bioavailable form of vitamin A. Retinoic acid receptor alpha (RARα) is the high affinity receptor for ATRA that mediates these pro-Th2 effects. We have previously characterized two major human Th2 subpopulations: IL-5- Th2 (IL-5-, IL-4+, IL-13+) and IL-5+ Th2 cells (IL-5+, IL-4+, IL-13+), which represent less ...

The prevalence of allergic diseases continues to increase worldwide along with industrialization and urbanization. Emerging evidence provides insights into the connection between development chronic inflammatory disorders, such as asthma allergies, human microbiota through immune-modulatory function commensal microbes.1, 2 In addition well-established on role gut in health disease, other microb...

BACKGROUND Storage mites are a source of aeroallergens that affect patients with allergic rhinitis and asthma. Tyrophagus putrescentiae is a causative factor of airway hypersensitivity, but the mechanisms and pathogenesis of Tputrescentiae-induced allergy are not well understood. OBJECTIVE This study aimed to develop a murine model of T putrescentiae-induced allergic asthma. METHODS Immune ...

Surgery is the only potentially curative option for patients with pancreatic ductal adenocarcinoma (PDAC), but metastatic relapse remains common. We hypothesized that the expression levels of inflammatory cytokines could predict recurrence of PDAC, thus allowing to select patients who most likely could benefit from surgical resection. We prospectively collected plasma at diagnosis from 287 pati...

Experiments in vitro suggest that although interleukin 5 (IL5) stimulates the late stages ofeosinophil differentiation, other cytokines are required for the generation of eosinophil progenitor cells . In this study transgenic mice constitutively expressing the IL-5 gene were established using a genomic fragment of the 11,5 gene coupled to the dominant control region from the gene encoding human...

BACKGROUND AND PURPOSE Microglia are resident immunocompetent and phagocytic cells of central nervous system (CNS), which produce various cytokines and growth factors in response to injury and thereby regulate disease pathology. The purpose of this study is to investigate the effects of microglial transplantation on focal cerebral ischemia model in rat. METHODS Transient middle cerebral arter...

OBJECTIVE We report the first pediatric specific Phenome-Wide Association Study (PheWAS) using electronic medical records (EMRs). Given the early success of PheWAS in adult populations, we investigated the feasibility of this approach in pediatric cohorts in which associations between a previously known genetic variant and a wide range of clinical or physiological traits were evaluated. Althoug...