نتایج جستجو برای: il28b genotype
تعداد نتایج: 91816 فیلتر نتایج به سال:
OBJECTIVES Single-nucleotide polymorphisms (SNPs) near the interleukin (IL) 28B gene encoding a type III interferon (IFN-λ) are the most important genetic predictors of treatment response to hepatitis C virus (HCV). This retrospective study was undertaken to determine any association between IL28B SNPs and the development of viraemia in Epstein-Barr virus (EBV)-driven acute infectious mononucle...
BACKGROUND To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. METHODOLOGY/PRINCIPAL FINDINGS Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN...
Infection by the hepatitis C virus (HCV) is a big threat to human health all over world. Many host factors could affect treatment response in HCV infection. One of these IL28B gene polymorphism. This research study investigated association (rs8099917) polymorphism with patients chronic infection receiving combination Sovaldi, Daklinza, and Ribavirin Egypt. The included 100 patients, divided int...
conclusions our study comprehensively explored the predictive factors of therapeutic effect of administered drugs and analyzed viral relapse during a six-months to six-year follow-up period from china. the svr may not be the perfect endpoint of hcv therapy in chinese people; we recommend 48 weeks after treatment withdrawal as the suitable time point. patients and methods we retrospectively anal...
BACKGROUND Hepatitis C virus (HCV) infection is associated with the development of cirrhosis and hepatocellular carcinoma and is also related to fatty change of the liver. Variation in patatin-like phospholipase domain-containing 3 (PNPLA3) gene is associated with disease progression in nonalcoholic fatty liver disease (NAFLD). Recent reports have suggested that PNPLA3, IL28B and TLR4-associate...
Chronic hepatitis C (CHC) affects approximately 170 million people worldwide, and over 3 million individuals are newly infected each year. Kim et al reported that the adjusted prevalence rate of hepatitis C virus (HCV) infection in the general Korean population is approximately 0.78%, and the prevalence has been increasing. HCV is an important cause of liver diseases, such as liver cirrhosis an...
BACKGROUND Virological response to peginterferon + ribavirin (P+R) at week 4 can predict sustained virological response (SVR). While patients with rapid virological response (RVR) do not require triple therapy, patients with a decline <1 log10 IU/ml HCVRNA (D1L) should have treatment discontinued due to low SVR rate. AIM To develop a tool to predict first 4 weeks' viral response in patients w...
BACKGROUND Abnormal serum lipid profiles have been noted in patients with chronic hepatitis C virus (HCV) infection. Moreover, many reports suggest that serum lipoprotein profiles are more profoundly distorted in patients with HCV G1b infection who have an unfavorable response to pegylated interferon (peg-IFN) plus ribavirin (RBV) combination therapy. However, after the discovery of single nucl...
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