Abstract The glioblastoma microenvironment is an immunosuppressive barrier to therapeutic innovation. We hypothesized intratumor convection enhanced delivery (CED) of gene therapy vectors could reprogram the immune and elucidate vulnerabilities. To test this, SB28 or GL261 allografts were implanted into immunocompetent mice treated with CED attenuated adeno-associated virus 9 (AAV9) encoding ex...

Acidotic conditions in the rumen have been associated with compromised barrier function of ruminal epithelium and translocation microbe-associated molecular patterns (MAMP) such as lipopolysaccharide (LPS). Interaction MAMP may also induce a local proinflammatory response. The aim this study was to evaluate potential response following LPS exposure Ussing chambers, investigate whether affects f...

BACKGROUND IgG4-related disease often forms a mass and the affected lesion is clinically removed because the mass cannot be differentiated from a neoplasm. Affected lesions commonly occur in the pancreas, hepatobiliary tract, kidney, and retroperitoneum. However, the lesion rarely occurs in the thymus. A histological worldwide consensus of IgG4-related disease proposed that pathological diagnos...

BACKGROUND Inflammatory processes and infections of the uterine wall must be accepted as a physiological event in dairy cows after calving. This might result in clinical or subclinical endometritis which is assumed to impair reproductive performance in the current lactation. Several cytokines and acute phase proteins have been discussed as local and systemic mediators of these inflammatory proc...

The cold inducible RNA binding protein (CIRBP) responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. CIRBP can bind the 3’untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. Here we used RNA interference and oligonucleotide micr...

BACKGROUND Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against bone loss in AIA and in monoarticular AIA (MAIA). METHODS Joint inflammation, trabecular bone loss, and osteoclastogenesis were evaluated in rats with AIA treated with PRL (via os...

Other names: Catabolin; IL-1; IL-1B; IL1-BETA; IL1F2; pro-interleukin-1-beta HGNC (Hugo): IL1B Location: 2q13 Note: IL-1beta is a pro-inflamatory cytokine and is expressed by many cells including macrophage, NK cells, monocytes, and neutrophils. It belongs to the IL-1 family cluster that includes the IL-1a, and IL1-RN genes. The caspase 1 (CASP1/ICE) gene proteolitically activates IL-1β. This g...

Root resorption (RR) is one of the most common sequelae of orthodontic treatment. A key role for a genetic influence in external apical root resorption (EARR) was described recently, by describing both linkage and linkage disequilibrium between interleukin-1B (IL-1B) and EARR in orthodontically treated individuals, accounting for approximately 15% of the variation in EARR. The murine model, whi...