The 70 C-terminal amino acids of Wiskott-Aldrich syndrome protein (WASp WA) activate the actin nucleation activity of the Arp2/3 complex. WASp WA binds both the Arp2/3 complex and actin monomers, but the mechanism by which it activates the Arp2/3 complex is not known. We characterized the effect of WASp WA on actin polymerization in the absence and presence of the human Arp2/3 complex. WASp WA ...

Proof of Theorem 4. For wa ∈ [c + ck, rck w−c ], we have the boundary equilibrium. From its definition, yb(ξ) is decreasing in wa (that is, dyb(ξ) dwa < 0) and yb(ξ) = μ + ξ + G−1( r−c−ck r ) when wa = c + ck. The total supply chain profit at the boundary equilibrium is Πtot(yb(ξ), yb(ξ), ξ) = rEmin(μ + ξ + , yb(ξ)) − (c + ck)y(ξ) from Equations (16) and (17). This function is concave and incre...

University of Washington, Department of Medicine, Division of Medical Genetics, Seattle, WA 98195, USA University of Washington, Department of Pathology, Seattle, WA 98195 University of Washington, Department of Medicine, Division of Oncology, Seattle, WA 98195 Fred Hutchinson Cancer Research Center, Seattle, WA 98195, USA Shanghai Sunway Biotech, No.1150, GuiQiao Road, Pudong, Shanghai 201206,...

In order to determine the presence and extent of obstructive pulmonary vascular disease in patients with congenital heart disease, magnified cineangiograms were obtained with a catheter in the pulmonary artery wedge position in 155 infants and children undergoing cardiac catheterization. The wedge angiograms (WA) were analyzed in groups according to the pulmonary hemodynamics: group A normal pu...

BACKGROUND Efficacy of withaferin A (WA), an Ayurvedic medicine constituent, for prevention of mammary cancer and its associated mechanisms were investigated using mouse mammary tumor virus-neu (MMTV-neu) transgenic model. METHODS Incidence and burden of mammary cancer and pulmonary metastasis were scored in female MMTV-neu mice after 28 weeks of intraperitoneal administration with 100 µg WA ...

1 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA. 2 Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA. 3 Department of Obstetrics and Gynecology, School of Medicine, University of Washington, Seattle, WA. 4 Group Health Center for Health Studies, Seattle, WA. 5 Current affiliation: Epidemiol...

Bank Mega Syariah Palu Branch applies the qardh contract to a multi financial product that is used in conjunction with Hawalah contract, and Ijarah (fee) contract. Qardh loan according distribution of funds based on agreement between borrower bank accordance sharia principle. This Indonesia law system Fatwa No. 79/DSN-MUI/2011. products are manifested from principles Islamic economic leading wo...

Withaferin A (WA) is a bioactive compound derived from a medicinal plant Withania somnifera and has potential therapeutic effects against various types of cancers. The purpose of this study is to investigate an apoptotic effect of WA and identify its molecular target in HSC-3 and HSC-4 human oral cancer cell lines using Trypan blue exclusion assay, DAPI staining and western blotting. WA inhibit...

M J OWEN* , P J MICHAEL , M RENTON* §, K J STEADMAN– & S B POWLES* *Australian Herbicide Resistance Initiative, University of Western Australia, Crawley, WA, Australia, School of Agriculture and Environment, Division of Science and Engineering, Curtin University of Technology, Northam, WA, Australia, School of Plant Biology, University of Western Australia, Crawley, WA, Australia, §CSIRO Sustai...

A. H. FULLERTON*, K. M. BURNETT , E. A. STEEL, R. L . FLITCROFT, G. R. PESS* , B . E. FEIST* , C. E . TORGERSEN , D. J . MILLER AND B.L. SANDERSON* *NOAA Northwest Fisheries Science Center, Seattle, WA, U.S.A. USDA Forest Service and Oregon State University, Corvallis, OR, U.S.A. USDA Forest Service, Pacific Northwest Research Station, Olympia, WA, U.S.A. USGS Forest and Rangeland Ecosystem Sci...