Background: Nasal polyps, a common clinical problem, are characterized by eosinophilic and mast cell inflammation.  The role of allergy and IgE in pathogenesis of nasal polyps is still unclear.  IgE receptors are important components of the immunological pathway in allergic and inflammatory diseases. Objective: To determine if the low affinity IgE receptor (CD23) is presented on nasal polyp tis...

PURPOSE Juvenile myoclonic epilepsy (JME) is a common, well-defined epileptic syndrome. This study aims to examine the clinical and EEG features of probands with JME and to identify the incidence of different types of idiopathic generalized epilepsies (IGEs) and IGE trait in first-degree relatives. METHODS Clinical and EEG data were collected from 132 first-degree relatives and 31 probands wi...

Abstract IgE mediated mast cell activation is a key feature of allergic disease, although the mechanisms that govern homeostasis are not fully understood. The TGFb signaling pathway has been shown to regulate effector function. Furthermore, variants in associated with diseases; regulation likely involved allergy diathesis. Patients Loeys Dietz Syndrome (LDS), disorder caused by loss function TG...

BackgroundAlpha-gal syndrome (AGS) is an emerging immunoglobulin E (IgE)–mediated allergy to galactose-alpha-1,3-galactose (alpha-gal). The geographic distribution and burden of AGS in the United States are unknown.ObjectiveTo characterize alpha-gal IgE testing patterns describe trends from 2010 2018 States.MethodsThis retrospective analysis included all persons tested for antibodies by Viracor...

Abstract Dysregulated expansion and/or activation of mast cells have detrimental consequences in allergic disease. In humans, homozygous or compound heterozygous deletions DOCK8 cause a combined immunodeficiency characterized by disorders. Based on this evidence, we hypothesized that may be negative regulator cell function. To address hypothesis, used mice with loss-of-function mutation Dock8 (...

BACKGROUND Job's syndrome (hyper IgE syndrome) is a very rare primary immunodeficiency disease that has an annual approximate incidence of less than 1/1,000,000. This manuscript aims to provide education regarding diagnosis and management strategies of this syndrome worldwide. CASE REPORT A 6-year-old boy was seen at the clinic secondary to persistent pruritus interfering with sleep. At the a...

Egg allergy is the commonest infant food allergy both in Australia and world-wide. The clinical presentation of egg allergy is varied - egg is involved in both IgE and non-IgE-mediated allergic reactions and has been implicated in conditions such as anaphylaxis, food protein-induced enterocolitis syndrome, atopic dermatitis and eosinophilic oesophagitis. The clinical presentation, pathophysiolo...

Background A considerable number of pollen-allergic patients develops allergy to plant foods, which has been attributed to crossreactivity between food and pollen allergens belongs to PR-10 proteins. The majority of these patients refuse from take the foods containing PR-10 explaining bad taste or sense of itch in the mouth syndrome of oral allergy (SOA). It is assumed that the primary is sensi...