Background IgA Deficiency (IgAD) is the most common immunoglobulin deficiency, with approximate incidence of 1 in 400 to 3000 individuals in general population. Selective IgA deficiency is defined as serum IgA levels less than 7 mg/dL with normal serum IgM and IgG levels. A subgroup of individuals, with more than 7 mg/dL but less than 30 mg/dL of serum IgA, are defined as partial IgA deficient ...

Antibodies to nucleic acid antigens were measured in symptomatic and asymptomatic IgA-deficient individuals, non-IgA-deficient blood donors, and patients with systemic lupus erythematosus (SLE). There was no increase in mean levels of antibodies to nucleic acid antigens (native or denatured DNA, transfer RNA) in the IgA-deficient group, although 4 of 100 IgA-deficient blood donors had persisten...

Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The typical clinical course and histology in these two patients suggest that IgA-me...

Question: I understand that anti-IgA antibodies are quite rare in patients with IgA deficiency, but, when starting intravenous immunoglobulin (IVIG) in patients with common variable immune deficiency and with very low serum IgA levels, is the product with the lowest IgA concentration, the only choice or could one choose a product with a low IgA concentration (<25 mg/mL)? I know that subcutaneou...

INTRODUCTION Dermatitis herpetiformis (DH) seems to be a chronic immune-mediated inflammatory disease of partially known origin. In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their...

BACKGROUND Whooping cough is a respiratory disease caused by Bordetella pertussis, which induces mucosal IgA antibodies that appear to be relevant in protection. Serum IgA responses are measured after pertussis infection and might provide an additional role in pertussis diagnostics. However, the possible interfering role for pertussis vaccinations in the induction of serum IgA antibodies is lar...

IgA plays a key role in immune defence of the mucosal surfaces. IgA can trigger elimination mechanisms against pathogens through the interaction of its Fc region with FcaRs (receptors specific for the Fc region of IgA) present on neutrophils, macrophages, monocytes and eosinophils. The human FcaR (CD89) shares homology with receptors specific for the Fc region of IgG (FcyRs) and IgE (FceRIs), b...

IgA is one of the five classes of immunoglobulin found in biological fluids. It is the major secretory immunoglobulin and is widely distributed in all mucosal secretions as a dimeric molecule linked by a joining chain and a third molecule, the secretory piece. The dimeric form is resistant to proteolytic digestion and IgA antibodies are important in the protection of mucous membranes against in...