The equine herpesvirus 1 (EHV-1) immediate-early (IE) and EICP0 proteins are potent trans-activators of EHV-1 promoters; however, in transient-transfection assays, the IE protein inhibits the trans-activation function of the EICP0 protein. Assays with IE mutant proteins revealed that its DNA-binding domain, TFIIB-binding domain, and nuclear localization signal may be important for the antagonis...

The aim of this study was to determine the role of small intestinal (SI) cytochrome P450 (P450) enzymes in the metabolic activation of diclofenac (DCF), a widely used nonsteroidal anti-inflammatory drug, and DCF-induced intestinal toxicity. DCF induces intestinal ulcers in humans and mice, but the underlying mechanisms, including the necessity for drug bioactivation in the target tissues and th...

the title compound has been synthesized starting from 2-methoxybenzdiethylarnide (1).

Abstract Study objectives To investigate circadian typology in a large, representative sample of Norwegian adolescents, and its implications for sleep health. Methods The included 3920 1st year high school students aged 16–17 years. Respondents completed web-based survey, including the short version Horne-Ostberg Morningness-Eveningness Questionnaire (rMEQ), Munich Chronotype (MCTQ) items on sl...

This study determined the effect of a high vs low resistive inspiratory muscle interval training protocol on inspiratory muscle strength (PImax), incremental inspiratory threshold loading (Pitl), inspiratory muscle endurance (IE), and 12-minute distance test (12 MD) in severely impaired patients with COPD. We used a double-blind, two-group, repeated-measure design. Group 1 (n = 12) received sup...

a total of 14 cases of infective endocarditis (ie) in children aged 6 months to 10 years were seen from december 1987 to december 1992 at the pediatric unit of ayatollah taleghani medical center. the majority of patients (12 of 14) were between 5 and 10 years of age. acyanotic congenital heart disease was known to preexist in 78.6% and rheumatic valvular heart disease in 21.4% of cases. organis...

BACKGROUND Acquired immunodeficiency syndrome (AIDS) is a pandemic disease commonly associated with respiratory infections, hypoxemia, and death. Noninvasive PEEP has been shown to improve hypoxemia. In this study, we evaluated the physiologic effects of different levels of noninvasive PEEP in hypoxemic AIDS patients. METHODS Thirty AIDS patients with acute hypoxemic respiratory failure rece...