نتایج جستجو برای: ido

تعداد نتایج: 2175  

2014
Rachel Tanner Kristina Kakalacheva Ellen Miller Ansar A Pathan Rod Chalk Clare R Sander Tom Scriba Michelle Tameris Tony Hawkridge Hassan Mahomed Greg Hussey Willem Hanekom Anna Checkley Helen McShane Helen A Fletcher

BACKGROUND There is an urgent need for improved vaccines to protect against tuberculosis. The currently available vaccine Bacille Calmette-Guerin (BCG) has varying immunogenicity and efficacy across different populations for reasons not clearly understood. MVA85A is a modified vaccinia virus expressing antigen 85A from Mycobacterium tuberculosis which has been in clinical development since 2002...

Journal: :Transplantation proceedings 2012
N Suarez-Fuentetaja N Domenech-Garcia M J Paniagua-Martin R Marzoa-Rivas E Barge-Caballero Z Grille-Cancela J Pombo-Otero J Muñiz-García A Castro-Beiras M G Crespo-Leiro

BACKGROUND The indoleamine, 2-3 dioxygenase (IDO) is an inducible intracellular enzyme with immunosuppressive effects mainly on lymphocyte populations. It has been postulated that indirect determination of IDO serum activity may be a marker of renal graft rejection, but its potential usefulness in heart transplantation (HT) is unknown. METHODS This longitudinal study included 98 HT patients (...

2015
Arta M Monjazeb Michael Kent Steven K Grossenbacher William Murphy

Immunotherapy can paradoxically up-regulate immunosuppressive pathways, a phenomenon we term “rebound immunosuppression”. One such pathway is the immunosuppressive enzyme indolamine-2,3-dioxygenase (IDO). Here, we postulated that IDO blockade will improve immunotherapy efficacy by preventing rebound immune-suppression. It has been previously shown that immunotherapy consisting of intralesional ...

Journal: :Journal of immunology 2009
Toshiharu Onodera Myoung Ho Jang Zijin Guo Mikako Yamasaki Takako Hirata Zhongbin Bai Noriko M Tsuji Daisuke Nagakubo Osamu Yoshie Shimon Sakaguchi Osamu Takikawa Masayuki Miyasaka

Dendritic cells (DCs) express the immunoregulatory enzyme IDO in response to certain inflammatory stimuli, but it is unclear whether DCs express this enzyme under steady-state conditions in vivo. In this study, we report that the DCs in mesenteric lymph nodes (MLNs) constitutively express functional IDO, which metabolizes tryptophan to kynurenine. In line with a previous report that regulatory ...

Journal: :American journal of physiology. Heart and circulatory physiology 2011
Stephanie W Watts Samantha Shaw Robert Burnett Anne M Dorrance

Indoleamine 2,3-dioxygenase (IDO) metabolizes L-tryptophan to L-kynurenine, promotes immunosuppression, and has been described as a consumer of superoxide. We discovered IDO expression in periaortic fat and tested the hypothesis that periarterial IDO functionally reduces agonist-induced contraction. Our model was the thoracic aorta, abdominal aorta, and superior mesenteric artery of the male Sp...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Jennifer E Cole Nagore Astola Adam P Cribbs Michael E Goddard Inhye Park Patricia Green Alun H Davies Richard O Williams Marc Feldmann Claudia Monaco

Atherosclerosis is the major cause of cardiovascular disease (CVD), the leading cause of death worldwide. Despite much focus on lipid abnormalities in atherosclerosis, it is clear that the immune system also has important pro- and antiatherogenic functions. The enzyme indoleamine-2,3-dioxygenase (IDO) catalyses degradation of the essential amino acid tryptophan into immunomodulatory metabolites...

2017
Clement G Adu-Gyamfi Tracy Snyman Christopher J Hoffmann Neil A Martinson Richard E Chaisson Jaya A George Melinda S Suchard

Background There is no biomarker for diagnosing active tuberculosis in patients with human immunodeficiency virus (HIV) infection. Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulatory enzyme that breaks down tryptophan (Trp) to metabolites known as kynurenines (Kyns). We investigated whether IDO activity, as measured by the ratio of Kyn to Trp, could be used to diagnose or predict active t...

2010
Albert Goldfain Barry Smith Lindsay G. Cowell

This paper addresses the use of dispositions in the Infectious Disease Ontology (IDO). IDO is an ontology constructed according to the principles of the Open Biomedical Ontology (OBO) Foundry and uses the Basic Formal Ontology (BFO) as an upper ontology. After providing a brief introduction to disposition types in BFO and IDO, we discuss three general techniques for representing combinations of...

Journal: :Cancer research 2005
Alexander J Muller George C Prendergast

Activation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facilitates immune escape. A recent study now shows how small-molecule inhibitors of IDO can be used to leverage the efficacy of traditional chemotherapeutic drugs that are used to treat cancer in the clinic. By promoting antitumor immune responses in combination with cytotoxic chemotherapy, IDO i...

Journal: :Cancer research 2007
Richard Metz James B Duhadaway Uma Kamasani Lisa Laury-Kleintop Alexander J Muller George C Prendergast

Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer therapeutics. One issue related to trials of the clinical lead inhibitor, D-1-methyl-tryptophan (D-1MT), concerns the extent of its biochemical specificity for IDO. Here, we report the discovery of a novel IDO-related tryptophan catabolic enzyme termed IDO2 that is pr...

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