Identifying viral mutations that confer escape from antibodies is crucial for understanding the interplay between immunity and viral evolution. We describe a high-throughput approach to quantify the selection that monoclonal antibodies exert on all single amino-acid mutations to a viral protein. This approach, mutational antigenic profiling, involves creating all replication-competent protein v...

Multifunctionality is a well observed phenomenological feature of biological neural networks and considered to be fundamental importance the survival certain species over time. These multifunctional are capable performing more than one task without changing any network connections. In this paper, we investigate how neurological idiosyncrasy can achieved in an artificial setting with modern mach...

Idiosyncratic reactions occur in a small fraction (typically <5%) of the population taking therapeutic drugs. Chlorpromazine (CPZ) is a phenothiazine, antipsychotic drug that has caused several idiosyncratic responses during its therapeutic use. Clinical evidence suggests that conditions associated with inflammation are risk factors for the appearance of these responses. Accordingly, we tested ...

Introduction Current literature on gesture research states that the question “why different gestures take the particular physical form they do is one of the most important yet largely unaddressed questions in gesture research” [1, p. 499]. This holds especially for iconic gestures, for which information has to be mapped from some mental image into (at least partly) resembling gestural form. Thi...

The present study aims to understand an ill-defined sensory concept by a long-term memory-based strategy with Spanish winemakers from four wine regions using “green wine” as case study. A total of 77 carried out non-tasting free description task. task yielded terms belonging two main categories including origin-related well terms. Sensory belonged aroma, taste, trigeminal, colour, multimodal an...

A In the medical field, Image dispensation techniques are extensively employed for image amelioration in finding and treatment of lung disease big data environment, where point time feature is very paramount to determine idiosyncrasy issues intention images, particularly such as cancer, pneumonia, COVID-19 etc, early detection stages lungs disease, processing technique widely used identificatio...

Sex, age, emotional state of the subject, pathological voices ... are characteristics than allow us recognise different speakers. The accent difference persons of different regions, indeed their tone establish inequality between analogous voices; intensity and timbre differ voices with similar tones; pauses, tempo, idea's speed ... condition an unique and discriminate voice for each speaker. Pr...