Granulomatous mastitis (GM) is a rare chronic inflammatory breast condition with unknown etiology. There is still no generally accepted optimal treatment for GM. Corticosteroid treatment and/or wide excision is most commonly reported in the literature. Incision and drainage or limited excision alone has little benefit because of a strong tendency of recurrence. Corticosteroids also have a high ...

We report the first case of granulomatous mastitis due to Corynebacterium kroppenstedtii linked to strongly impaired neutrophil responses to Nod2 agonist and a single nucleotide polymorphism within the NOD2 gene (SNP13 [Leu1007fsinsC]) in a heterozygous state. These findings provided the first demonstration of impaired Nod2 function associated with corynebacterial infection.

Background Idiopathic Granulomatous mastitis (IGM) is a chronic benign inflammatory breast disease characterized by non-caseating granuloma with multinucleate giant cells and micro-abscesses[1]. It presents as painful lump, axillary lymphadenopathy, nipple retraction, peau d’orange appearance of the skin mimicking cancer [1]. Till date, there are no consensus guidelines managing IGM it increasi...

b Strep. agalactiae is easily cured by approved antibiotic infusion products. b Therapy of Staph. aureus mastitis greatly improves with extended or combination therapy. b Extra-label treatment requires a valid veterinary/patient/client relationship. b Oxytocin is effective in alleviating clinical symptoms of coliform mastitis. b Antibiotics are more effective against Gram-positive than Gram-neg...