BACKGROUND Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42 protein level...

With support for C/C++, Fortran, MPI, OpenMP, and performance tools, the Eclipse integrated development environment (IDE) is a serious contender as a programming environment for parallel applications. There is interest in adding capabilities in Eclipse for conducting workflows where an application is executed under different scenaries and its outputs are processed. For instance, parametric stud...

Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat insulin degrading enzyme (IDE) to serines resulted in a cysteine-free form of the enzyme with reduced activity and decreased activation by polyanions. Mutation of each cysteine residue individually revealed cysteine 904 as the key residu...

Classical compiler architecture is centred around producing object code in a batch-oriented fashion. Integrated development environments (IDEs) present new challenges to the language implementer: information should be (almost) instantly available, presented even for incorrect code, and should be dynamically updated as the user is editing. To increase responsiveness, it may be necessary to compu...

Golenkinia, Chlorella protothecoides, and mutant C-2A' of Scenedesmus were grown in darkness and on media in which chlorophyll synthesis is reduced significantly. The pigments were analyzed by spectrophotometry or by paper chromatography and compared with similar extracts from light-grown algae and dark-grown beans. No protochlorophyll(ide) was present in the dark-grown algae indicating that ch...

For years, Integrated Development Environments have demonstrated their usefulness in order to ease the development of software. High-level security or safety systems require proofs of compliance to standards, based on analyses such as code review and, increasingly nowadays, formal proofs of conformance to specifications. This implies mixing computational and logical aspects all along the develo...