OBJECTIVES This study sought to compare findings from institutional echocardiographic reports with imaging core laboratory (ICL) review of corresponding echocardiographic images and operative reports in 159 patients with anomalous aortic origin of a coronary artery (AAOCA). The study also sought to develop a "best practice" protocol for imaging and interpreting images in establishing the diagno...

OBJECTIVE Myocardial swelling occurs during endotoxic shock. The hypothesis that swelling-activated Cl- current (ICl,swell) activates during endotoxic shock was tested. METHODS Endotoxic shock was induced by intravenous lipopolysaccharides (10 mg/kg) in guinea pigs. The effects of ICl,swell blockers on the cardiac action potentials in papillary muscles and on the ICl,swell in single ventricul...

The Covid 19 pandemic requires critical re-evaluation of the way Higher Education can help students maximise their learning to adjust and adapt a new reality. This holistic approach which extends beyond consideration student in formal settings understanding role informal play. Whilst research exists on independent learning, less focus has been placed how collaborate informally as part process. ...

Peroxisomes are organelles that sequester certain metabolic pathways; many of these pathways generate H(2)O(2), which can damage proteins. However, little is known about how damaged or obsolete peroxisomal proteins are degraded. We exploit developmentally timed peroxisomal content remodeling in Arabidopsis thaliana to elucidate peroxisome-associated protein degradation. Isocitrate lyase (ICL) i...

Drugs that produce covalent interstrand cross-links (ICLs) in DNA remain central to the treatment of cancer, but the cell cycle checkpoints activated by ICLs have received little attention. We have used the fission yeast, Schizosaccharomyces pombe, to elucidate the checkpoint responses to the ICL-inducing anticancer drugs nitrogen mustard and mitomycin C. First we confirmed that the repair path...

Mycobacterium tuberculosis (Mtb) represents one of the most persistent bacterial threats to human health and new drugs are needed to limit its impact. Conditional knockdown mutants can help validate new drug targets, but the analysis of individual mutants is laborious and time consuming. Here, we describe quantitative DNA tags (qTags) and their use to simultaneously analyze conditional Mtb knoc...

This paper describes ICL’s participation at RTE-7. We chose the Main task. Textual entailment is a problem to predict whether an entailment holds for a given test-hypothesis pair. We built an inference model to solve this problem by means of using dependency syntax analysis (by Stanford Parser), lexical knowledge base (e.g. Wordnet), web information (e.g. Wikipedia) and probability method.

INTRODUCTION: To compare the surgical outcomes of anterior chamber (AC) and posterior (PC) implantation iris claw lens (ICL) combined with penetrating corneal transplantation (P-CT), in eyes no capsular support. METHODS: The records 20 P-CT cases who underwent ICL were retrospectively evaluated. grouped according to location implantation; AC PC ICL. Pre- post-surgical best-corrected visual acui...

The aim of the study was to develop a theoretical indicator of upper limb musculoskeletal load based on repetitive task parameters. As such the dimensionless parameter, Integrated Cycle Load (ICL) was accepted. It expresses upper limb load which occurs during 1 cycle. The indicator is based on a model of a repetitive task, which consists of a model of the upper limb, a model of basic types of u...

At the beginning of the HIV/AIDS epidemic in the 1980s, the medical community learned about a subset of patient population who presented with opportunistic infections, had severely depressed CD4 T cell counts, but to everyone’s surprise these patients did not have HIV infection and there was no other explanation to account for their immunodeficiency [15]. Emergence of these anomalous findings l...