Aim: We demonstrated the risk of developing islet autoantibodies-Insulin Autoantibodies (IAAs) and Islets cell Autoantibodies (ICAs)-in type-1 diabetic relatives and newly diagnosed type-1 patients compared to non-diabetic controls. We also aimed to determine the predictive strengths of both autoantibodies in the development of type-1 diabetes mellitus, and which of the two autoantibodies is a ...

BACKGROUND AND PURPOSE Difficulties in data presentation, data storage, and a high interobserver variability may influence color-coded Duplex sonography assessment of internal carotid artery stenosis (ICAS). The aim of our study was to evaluate the between-method agreement of ICAS using 3D color Doppler sonography (CDS) compared with digital subtraction angiography (DSA). METHODS Forty-nine p...

Objective Many patients receiving dual antiplatelet therapy still had recurrent strokes. We aimed to identify factors associated with recurrent stroke at 90 days in patients receiving dual antiplatelet therapy in Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial. Methods Patients with transient ischaemic attack or minor stroke receiving clopidogrel and as...

PURPOSE To examine whether an abnormally thin retinal nerve fiber layer (RNFL) is associated with cerebrovascular insufficiency. DESIGN Community-based study. METHODS The Asymptomatic Polyvascular Abnormalities in Community Study included Chinese aged 40+ years and without histories of cerebrovascular incidents or coronary heart disease. Using transcranial Doppler and carotid duplex ultraso...

STUDY OBJECTIVES To describe the characteristics and outcomes of patients admitted to intermediate-care areas (ICAs) and to compare them with those of ICU patients who receive monitoring only on day 1 and are at a low risk (i.e., < 10%) for receiving subsequent active life-supporting therapy (i.e., low-risk monitor patients). DESIGN Nonrandomized, retrospective, cohort study. SETTING Thirte...

INTRODUCTION The SAMMPRIS trial suggested that aggressive treatment was superior to endovascular stenting in patients with severe symptomatic intracranial atherosclerotic stenosis (ICAS) due to high complication rates in patients in the stenting group. Given that 12.2% patients failed aggressive medical therapy in the SAMMPRIS study, it is imperative to perform a multicentre prospective registr...

Distribution Statement ”A” (Approved for Public Release, Distribution Unlimited) Abstract—Incident response teams that are charged with breach discovery and containment face several challenges, the most important of which is access to pertinent data. Our TAPIO (Targeted Attack Premonition using Integrated Operational data) tool is designed to solve this problem by automatically extracting data ...

OBJECTIVE We sought to study the prevalence of autoantibodies to various islet cell antigens in the background population of two neighboring countries with a sixfold difference in the incidence of type 1 diabetes. RESEARCH DESIGN AND METHODS Serum samples were obtained from 3,652 nondiabetic schoolchildren in Finland and from 1,988 schoolchildren in the adjacent Karelian Republic of Russia. T...

BACKGROUND/PURPOSE Identification of carotid near-occlusion is essential before calculation of percent stenosis because stroke risk is lower than other severe stenosis and the treatment benefit is less. Calculations with reduced distal diameters are fallacious. CT angiography (CTA) is convenient and accurately quantifies internal carotid artery (ICA) stenosis. METHODS In a blinded protocol, 2...

BACKGROUND AND PURPOSE We sought to investigate whether preoperative volume flow in the internal carotid arteries (ICAs), the basilar artery (BA), and the middle cerebral arteries (MCAs) and collateral flow via the circle of Willis differ between patients who do and patients who do not develop cerebral ischemia during clamping of the carotid artery in carotid endarterectomy (CEA). METHODS Qua...