نتایج جستجو برای: i و tgfb1
تعداد نتایج: 1792530 فیلتر نتایج به سال:
BACKGROUND The imbalance between proteases and antiproteases has been proposed to participate to the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. Gene level variation in different metalloproteinases, metalloproteinase inhibitors, and cytokines affecting them may contribute to this imbalance and destruction of the lung parenchyma. We investigated whether polymorphi...
Program Number: 5363 Poster Board Number: B0034 Presentation Time: 3:45 PM–5:30 PM FOXS1 drives EMT in retinal pigment, mammary and hepatic epithelial cells through p38 activation by TGFΒ1 and TNFa Timothy A. Blenkinsop1, Tomasz Swigut2, Nathan Boles3, Rajini Srinivasan2, Qingjie Wang3, Jeffrey Stern3, Joanna Wysocka2, Sally Temple3. 1Black Family Stem Cell Institute, Icahn School of Medicine a...
OBJECTIVES: Genetic susceptibility to cervical cancer in relation transforming growth factor beta 1 (TGFB1) gene polymorphisms has not been investigated extensively among the women Bangladesh. So, aim of this study was find out correlation TGFB1 C509T (rs1800469) and T869C (rs1800470) with risk Bangladeshi women. STUDY DESIGN: 134 patients 102 age-sex matched healthy controls were included from...
Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to promote T cell exhaustion and generation of regulatory T cells, which are shown to be deleterious in cancer, by the induction of transcription f...
A polymorphic allele in transforming growth factor h receptor 1 (TGFbR1) is hypothesized to increase risk of cancer (1). The allele, designated as TGFbR1*6A , results from the deletion of three alanines within a nine-alanine stretch in exon 1, and in vitro studies have shown that TGFbR1*6A is an impaired mediator of TGF-h antiproliferative signals compared with wild-type (TGFbR1*9A ; refs. 2, 3...
Background: STR/ort mice spontaneously develop degenerative changes of the knee joints resembling human osteoarthritis (OA), with the males being more severely affected than the females. Objective: To analyse the early changes leading to OA by examining the articular cytokine expression and degenerative changes in STR/ort mice. Methods: 122 STR/ort mice of both sexes aged between 2 and 15.5 mon...
BACKGROUND Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population....
Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis trea...
Objective—Transforming growth factor (TGF)1 (TGF1) is a multifunctional cytokine that exhibits vasculoprotective properties. Production and plasma levels of TGF1 are influenced by polymorphisms in the TGF1 gene (TGFB1). We investigated whether the 509C/T (rs1800469), 868T/C (rs1982073), 913G/C (rs1800471), and 11929C/T (rs1800472) polymorphisms of TGFB1 are associated with myocardial infarction...
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