Multifactorial Bases of Stroke After Cardiac Surgery To the Editor: We read with great interest the article by Gottesman et al1 dealing with one of the most devasting complications of cardiac surgery, perioperative stroke. The article analyzed the impact on outcomes of watershed stroke and the role of intraoperative hypoperfusion on its onset. Nevertheless, their report raises some concerns. Th...

Autism is a neurodevelopmental disorder currently affecting as many as 1 out of 166 children in the United States. Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation and gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, neurotransmitter abnormalities, impaired detoxification of tox...

A patient is reported who was treated successfully for a left thalamic abscess that resulted in subcortical aphasia. A SPECT scan showed large areas of hypoperfusion in the cortex of the left hemisphere. At follow up after seven months there was marked improvement in the language disorder and the cortical hypoperfusion. It is suggested that aphasia in patients with subcortical lesions results f...