Does Hypomagnesemia Have an Adaptive Role in Hypertension? To the Editor: Northcott and Watts investigate association of hypomagnesemia with hypertension; these authors conclude that activation of phosphatidylinositol 3-kinase by low extracellular magnesium concentration enhances arterial tone.1 As indicated by these authors, despite many experimental and clinical studies, the cause–effect rela...

Hypomagnesemia can lead to cardiac arrythmias. Recently, observational data have linked chronic proton pump inhibitor (PPI) exposure to hypomagnesemia. Whether PPI exposure increases the risk for arrhythmias has not been well studied. Using a large, single-center inception cohort of critically ill patients, we examined whether PPI exposure was associated with admission electrocardiogram reading...

BACKGROUND Stroke mimics may account for up to 30% of all acute stroke consultations. However, in the emergency setting, accurate diagnosis is not always possible. METHODS Case report and review of the literature. RESULTS A 73-year-old woman was admitted to the emergency department with acute aphasia and right hemiparesis. The National Institute of Health Stroke Score was 21, compatible wit...

Pseudohypoparathyroidism (PHP) is a rare disorder characterized by varying degrees of unresponsiveness to parathyroid hormone. Patients usually present with hypocalcemia-induced seizures or tetany, whereas no case of hypocalcemia-induced cardiac arrhythmia in PHP has been described to date. In this paper, we report the case of a male adolescent with PHP type 1a who presented with hypocalcemia-i...

BACKGROUND The authors describe dental and periodontal conditions of two Chinese sisters affected by familial hypomagnesemia with hypercalciuria and nefrocalcinosis (FHHNC). FHHNC is a rare syndrome, genetically investigated since 1999, transmitted as an autosomal recessive disease. It is related to a mutation of PCN-1 gene which encodes for a tight junction protein named paracellin. CASE REP...

DEAR EDITOR, Type 2 diabetes mellitus (T2DM) is a major global public health problem in the world-wide and is increasing in aging populations. We previously conducted a study entitled; lipids in association with serum magnesium in DM patients in 2008. In this study, on 122 patients, we found a significant inverse correlations of serum magnesium with serum cholesterol and low-density lipoprotein...

Abstract Background and Aims Gitelman syndrome (GS) is characterized by salt-losing hypotension, hypokalemic metabolic alkalosis, hypomagnesemia, hypocalciuria caused a specific mutation in the thiazide-sensitive sodium chloride co-transporter (NCC) gene SLC12A3. However, magnesium (Mg2+) associated distal renal tubules remains unclear. Method We performed small samples RNA-seq from manual micr...