To diagnose iron deficiency in patients undergoing hemodialysis, the percentage of hypochromic RBCs (with cellular hemoglobin concentration <280 g/L [HYPO%]) and mean reticulocyte hemoglobin content (CHret) provided by the Siemens ADVIA 120 and 2120 analyzers (Siemens Diagnostic Solutions, Tarrytown, NY) were proposed as alternatives to biochemical tests. Sysmex, with its XE-5000 analyzer (Sysm...

Changes in glycosylation are salient features of cancer cells. Here, we report on the diagnostic and therapeutic properties of IDK1, an antibody against tumour associated, hypoglycosylated bone sialoprotein (hypo-BSP). The affinity of the rat monoclonal antibody IDK1 for hypo-BSP, as determined by microscale thermophoresis, was three orders of magnitude higher than for mature BSP, whereas the m...

INTRODUCTION Hypogonadotropic hypogonadism (HH) is a heterogeneous disease caused by mutations in several genes. Based on the presence of hyposmia/anosmia it is distinguished into Kallmann syndrome (KS) and isolated HH. The prevalence of other developmental anomalies is not well established. METHODS We studied 36 patients with HH (31 males, 5 females, mean age 41.5), 9 with familial and 27 wi...

Patients with clinically well defined keratoconjunctivitis sicca (KCS) participated in two trials of hypo-osmolar tear substitutes. The trials were double masked, single crossover studies with computer generated random order allocation and were conducted by postal questionnaire. In the first trial a hypo-osmolar formulation using polyvinylpyrrolidone and hydroxyethyl cellulose was compared with...

PACIFIC regimen is the gold standard for patients with unresectable locally advanced Non-Small Cell Lung Cancer (NSCLC). Moving forward on developing best treatment combination, this study aims to assess safety and efficacy of a induction chemo-immunotherapy followed by de-intensified, hypo-fractionated RT given concurrently Durvalumab maintenance in unresectable, stage III NSCLC. Dedalus trial...

ObjectivesTo explore the efficacy and toxicities of split-course hypo-fractionated radiotherapy with concurrent chemotherapy (HFRT−CHT) intensity modulated (IMRT) technique in non-small cell lung cancer (NSCLC) patients postoperative locoregional recurrence (LRR).Materials MethodsNSCLC were eligible if confirmed as LRR disease without distant metastasis after complete resection. HFRT−CHT using ...

We give a simplified proof of regularizing effects for first-order Hamilton-Jacobi Equations of the form ut+H(x, t, Du) = 0 in R ×(0,+∞) in the case where the idea is to first estimate ut. As a consequence, we have a Lipschitz regularity in space and time for coercive Hamiltonians and, for hypo-elliptic Hamiltonians, we also have an Hölder regularizing effect in space following a result of L. C...