Introduction Vit D level is low in human milk (20-60 IU/Lit) thus dialy supplement of 400 Vit D is advised since birth for all infants. On the other hand upper limit dose for long term Vit D intake is 1000 IU/day for children less than one year of age. Excessive Vit D more than upper limit by physicians or parents can cause hypervitaminoseD. We report a rare case of hypervitaminose D in two mon...

introduction vit d level is low in human milk (20-60 iu/lit) thus dialy supplement of 400 vit d is advised since birth for all infants. on the other hand upper limit dose for long term vit d intake is 1000 iu/day for children less than one year of age. excessive vit d more than upper limit by physicians or parents can cause hypervitaminosed. we report a rare case of hypervitaminose d in two mon...

OBJECTIVES Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration. The inhibitory effect of all-trans retinoic acid on osteoblastogenesis is considered to be one of the mechanisms. We hypothesized that heterodimeric bone morphogenetic protein-2/7 could antagonize all-trans retinoic acid and enha...

In calcium homeostasis, vitamin D3 is a potent serum calcium-raising agent which in vivo regulates both calcitonin (CT) and parathyroid hormone (PTH) gene expression. Serum calcium is the major secretagogue for CT, a hormone product whose biosynthesis is the main biological activity of thyroid C-cells. Taking advantage of this regulatory mechanism, long-term vitamin D3-induced hypercalcemia has...

The skin is the only tissue in the human body that represents both a target tissue for biologically active vitamin D compounds including 1,25-dihydroxyvitamin D [1,25(OH)2D] and has the capacity for the synthesis of 1,25(OH)2D from 7-dehydrocholesterol (7-DHC). Recent findings indicate that the vitamin D endocrine system (VDES), besides multiple other important functions, regulates aging in man...

Caffey’s disease was characterized by a triad of symptoms, irritability, soft tissue swelling, and underlying cortical bone thickening. It mostly occurs before the first 5 months life in infancy. The knowledge this pathology essential as it masquerades wide range diseases including acute osteomyelitis, tumors, trauma, battered baby syndrome (child abuse), hypervitaminosis a, scurvy, infantile m...

Vitamin A is a pivotal biochemical factor required for normal proliferation and differentiation as well as for specialized functions, such as vision. The dietary intake of 1500 IU/day is recommended in the first year of life. Here, we report the case of an infant who had been given 62 000 IU/day for 80 days. The infant showed several clinical signs of retinol intoxication, including severe anem...