An 18-year-old man with known hypertrophic obstructive cardiomyopathy since age 9 was referred for evaluation. His mother had died suddenly at age 24, and her autopsy demonstrated hypertrophic obstructive cardiomyopathy. The patient was asymptomatic. His only medication was propranolol. Two-dimensional echocardiographic images demonstrated normal left ventricular size with hyperdynamic function...

A56-year-old asymptomatic man was identified in 1984 with an abnormal 12-lead ECG during a routine examination for a recreational pilot license. An ECG 2 years earlier was normal (Figure 1). Extensive work-up in 1984, including stress testing and coronary arteriography, showed no significant abnormality. In addition, an echocardiogram was within normal limits (Figure 2). In 1994, at 66 years of...

Echocardiographic studies were performed in 23 hypertensive patients who were receiving therapy with long-term hemodialysis. Five patients (22 percent) had normal thickness of the left ventricular wall. Eleven (48 percent) had symmetric left ventricular hypertrophy, and seven (30 percent) showed asymmetric septal hypertrophy, with a ratio of septal to posterior wall thickness of 1.3 or greater....

Hypertrophic obstructive cardiomyopathy is the most common genetic cardiac disease and is generally characterised by asymmetric septal hypertrophy and intraventricular obstruction. Patients with severe obstruction and significant symptoms that persist despite optimal medical treatment are candidates for an invasive septal reduction therapy. Twenty years after its introduction, percutaneous tran...

Eleven patients with hypertrophic obstructive cardiomyopathy and eight patients with idiopathic congestive cardiomyopathy underwent extensive neuromuscular studies to determine if a skeletal myopathy is associated with uncomplicated primary cardiomyopathy. The clinical examination revealed peripheral neuropathies in six patients, but no evidence of muscle weakness or atrophy. Nerve conduction s...

The presence of numerous abnormally arranged cardiac muscle cells in the ventricular septum has been considered a characteristic anatomic feature of patients with hypertrophic cardiomyopathy. To determine the specificity of this histologic marker for patients with hypertrophic cardiomyopathy, we used a quantitative method to determine the area of myocardium occupied by disorganized cells. In hy...

structive hypertrophic cardiomyopathy. J Clin Invest 66: 1369, 1980 30. Stefadouros MA, Canedo MI, Karayannis E, Abdulla A, Frank MJ: Internally recorded systolic time intervals in hypertrophic subaortic stenosis. Am J Cardiol 40: 700, 1977 31. Nesje OA, Enge I: External carotid pulse recordings in hypertrophic obstructive cardiomyopathy. Acta Med Scand 202: 197, 1977 32. Henry WL, Clark CE, Gr...

structive hypertrophic cardiomyopathy. J Clin Invest 66: 1369, 1980 30. Stefadouros MA, Canedo MI, Karayannis E, Abdulla A, Frank MJ: Internally recorded systolic time intervals in hypertrophic subaortic stenosis. Am J Cardiol 40: 700, 1977 31. Nesje OA, Enge I: External carotid pulse recordings in hypertrophic obstructive cardiomyopathy. Acta Med Scand 202: 197, 1977 32. Henry WL, Clark CE, Gr...

Electrocardiogram gated magnetic resonance imaging was performed in nine healthy volunteers, in four patients with pulmonary hypertension, and in 16 patients with hypertrophic cardiomyopathy. Fifty two short axis images in diastole were examined to assess the usefulness of magnetic resonance imaging for the measurement of the thickness of the free wall of the right ventricle and the degree of h...

The echocardiographic findings of eight patients with hypertrophic cardiomyopathy without outflow obstruction (HMC) and of 15 normal (Norm) individuals are presented. The characteristic features in HMC were: (1) interventricular septal width much greater than normal (HMC= 2.5 + 0.3 cm, Norm = 1.0 + 0.2 cm, P <0.005); (2) normal or only slightly increased posterior left ventricular wall thicknes...