Background and Objective: Prolonged use of hyperosmolar solution associated with mortality. Hypertonic sodium lactate as a new sodium-based does not yet have an evidence base that states long-term is safe in increasing ICP. Knowing the effect hypertonic on alterations level male wistar rats compared to mannitol Subject Method: This research animal experimental laboratory study using simple rand...

IN this issue of ANESTHESIOLOGY, Rozet et al. present the findings of a comprehensive study comparing two hyperosmolar agents, hypertonic saline (HS) and mannitol, for brain relaxation during craniotomy. This work calls into question whether sufficient information is now available to advocate substitution of mannitol with HS to promote brain relaxation during routine craniotomy. It was discover...

Background One of the main reasons for discharge lung donors is pulmonary edema. It may be associated to hemodynamic shock frequently present among organ donors. There is no experience using hypertonic saline solution among lung donors with hypovolemic shock. The aim of this study is to evaluate hypertonic solution in pulmonary function of lung donor model with hypovolemic shock using the ex-vi...

BACKGROUND The optimal prehospital fluid for the treatment of hypotension is unknown. Hypertonic fluids may increase circulatory volume and mute the pro-inflammatory response of the body to injury and illness. The purpose of this systematic review is to determine whether in patients presenting with hypotension in the prehospital setting (population), the administration of hypertonic saline (int...

Betaine is one of the major compatible osmolytes accumulated by kidney derived Madin-Darby canine kidney cells cultured in hypertonic medium. Betaine is accumulated by Na(+)- and Cl(-)-dependent uptake from the medium. To gain insight into the mechanism by which hypertonicity evokes an increase in the Vmax of the betaine transporter in Madin-Darby canine kidney cells, we measured the relative a...