Background The mechanisms involved in the etiology of adverse drug reactions (ADRs) are complex. A small proportion of ADRs are due to drug hypersensitivity where the immune response causes an unexpected and severe clinical reaction. The mechanisms of drug hypersensitivity are not yet fully understood, but genome wide screens have identified an association with HLA alleles and certain drugs. Fu...

This experiment pursued the time course of contact hypersensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) and histologic changes of the cutaneous reaction in mice. The contact hypersensitivity reached a maximum 4 days after sensitization (96.9 +/- 6.7% vs. 22.7 +/- 1.3% in control) and persisted for 3 weeks. The cutaneous hypersensitivity reaction showed peak reactivity at 24 hr after challenge...

Hyaluronidase is an enzyme that has temporary and reversible enzymatic effects on the matrix of connective tissue. When added to local anesthetics in pain treatments, it enhances their infiltration and dispersal into tissues. It is widely used in anesthesia for ocular, dental, and plastic surgery. Reports of drug hypersensitivity to hyaluronidase are rare and are usually confined to peribulbar ...

BACKGROUND Paclitaxel is used in the treatment of most gynecologic malignancies. It is solubilized in Cremophor EL, a polyoxyethylated castor oil agent responsible for the high rate of paclitaxel-associated hypersensitivity reactions. Abraxane, a newer, Cremophor-free form of albumin bound paclitaxel has demonstrated an activity and an improved toxicity profile in breast and lung cancers. CAS...

BACKGROUND Hypersensitivity pneumonitis has been described with exposure to aerosolized Mycobacterium avium complex (MAC) in indoor hot tubs (hot tub lung). OBJECTIVES To describe a case of MAC-associated hypersensitivity pneumonitis-like reaction possibly from showering and review previous hot tub lung reports. METHODS For the case report, we investigated a patient with histologically diag...

statement of the problem dental gloves are worn to protect dental care providers from contamination during contact with mucus membranes, blood and saliva. the prevalence of latex allergy has progressively increased due to the widespread use of protective disposable wears, especially latex gloves, among health care workers (hcw) in the past decade. the prevalence of latex allergy among hcw of ir...

Erythema nodosum (EN) is a delayed-type hypersensitivity reaction that most often presents as erythematous, tender nodules on the shins. Common triggers for EN include infection, drugs, pregnancy, malignancy, and inflammatory conditions, such sarcoidosis or gastrointestinal diseases; however, many cases are idiopathic. We present clinical case of 12 y.o girl with associated EBV.

Despite the widespread use of corticosteroids in children, hypersensitivity reactions to corticosteroids are rarely. However, life-threatening reactions have been described, and clinicians should be aware of the risk posted by potential allergy to corticosteroid. Parenteral administration of such corticosteroids as methylprednisolone and hydrocortisone is more commonly associated with severe hy...

Corticosteroids are rare causes of immediate type hypersensitivity reactions. We report a rare case of immediate type hypersensitivity reaction following an intralesional injection of triamcinolone acetonide into a presternal keloid. He had itching in and around the keloid along with an erythematous rash around the keloid, which had started 4 hours after the injection and had lasted for the nex...

background: pyrethroids are generally of low toxicity to humans, but in suicidal poisonings which are usually associated with ingestion of high doses, they lead to severe systemic effects. case report: a 30-year old woman presented to emergency department with a history of intentional ingestion of about 15 ml of prallethrin around 3 days earlier. she complained of shortness of breath along with...